When a person swallows, squeezing pressure is created to drive food and liquid down the throat to the esophagus (food tube). If a person has a swallowing impairment, meaning it is hard for him/her to swallow, he/she may need to use more squeezing pressure to drive the food or liquid down the throat to the esophagus. For this study, we want to examine the effect of making it harder to swallow (by placing a device around your neck that applies pressure to your neck) on how much squeezing pressure is needed to swallow liquids in normal people. After numbing the inside of your nose with numbing cream, we will use two instruments at the same time to measure this: 1) a small scope placed through your nose into the upper part of your throat, so that a camera can record the movements of your throat before and after swallowing and 2) a small catheter placed through your nose and fed into your stomach while you swallow, which records the squeezing pressures of the muscles in your throat and esophagus. We also want to see how much liquid remains in the throat after swallowing and how well the windpipe is protected from liquid entering it before, during, and after swallowing.
This research study will include patients undergoing esophagectomy. The purpose of this study is to determine the effectiveness of using a FDA approved monitor, the FloTrac monitor, to help determine how much fluid and blood pressure medications a patient receives during surgery to maintain a stable blood pressure.
Eosinophilic esophagitis is understood to be a chronic inflammatory disease characterized by the presence of esophageal eosinophilia in the clinic context of dysphagia. This disease has been further categorized into predominantly fibrostenotic and inflammatory phenotypes. It is believed that these two subtypes may represent a continuum of change and disease progression of the esophagus; with fibrostenotic changes developing over time. We have demonstrated in another study that intrabolus pressure as obtained via high resolution esophageal manometry can reliably differentiate these two subtypes. It is our hypothesis that intrabolus pressure may not only serve as a novel tool to differentiate these subtypes, but may serve as a novel objective marker to assess overall clinical severity of this disease. After thorough review of the current literature, there have yet been no studies demonstrating a reliable diagnostic modality to accomplish this objective. A novel prognostic marker would help further our understanding of eosinophilic esophagitis and help guide more focused management.
The study will compare two durations of treatment with Octreotide in patients with confirmed esophageal variceal hemorrhage who have undergone successful endoscopy and possible endoscopic therapy for control of bleeding. All procedures including the treatment are the standard of care. Octreotide infusion and endoscopic therapy for esophageal variceal bleeding are not investigational.
This study is to find the best time that a follow up appointment can be scheduled to benefit the patient with liver cirrohis to return after having the bleeding vessels in the esophagus repaired by directing a scope in the esophagus and using bands to stop the bleeding.