Establishment of a Registry for Patients Treated with Photodynamic Therapy (PDT) Save

Date Added
October 18th, 2018
PRO Number
Pro00082282
Researcher
Gerard Silvestri

List of Studies


Profiles_link
Keywords
Cancer, Cancer/Lung, Stage I, Stage II, Stage III, Stage IV
Summary

Photodynamic therapy (PDT) is a type of treatment used to treat cancer. The purpose of this research study is to collect information on patients treated with PDT so that we can determine if patient characteristics affect their response to PDT. We will collect information about medical history, life style habits like smoking, reports from the tissue taken during biopsy, and outcome of the treatment to include in the registry.

Institution
MUSC
Recruitment Contact
Katherine Taylor
843-792-2297
taylkat@musc.edu

A Study to Evaluate a Panel of Blood Biomarkers for Use in Patients Undergoing Evaluation for Lung Cancer, ONC-LN-04 Save

Date Added
June 5th, 2017
PRO Number
Pro00061266
Researcher
Gerard Silvestri

List of Studies


Profiles_link
Keywords
Cancer, Cancer/Lung, Lung, Pulmonary
Summary

The primary objective of this study is to develop a blood-based gene expression signature, known as the ONC-LN-04 Lung Test, to be used in the detection of lung cancer in patients who underwent radiologic screening for lung cancer and had lung nodules detected. We intend to enroll volunteers who are being evaluated by a Medical University of South Carolina (MUSC) pulmonologist as part of their standard medical care. Participants will be current or former smokers, who have either (a) radiologic evidence of lung nodules, or (b) a confirmed diagnosis of non-small cell lung cancer (NSCLC) and has not undergone surgical excision, chemotherapy or radiation therapy for this malignancy. A single blood sample will be obtained from willing participants, then stored and analyzed for measurement of gene expression and development of the ONC-LN-04 test. Active participation in this study will be over once a blood sample is obtained; however, we may need access to participants' medical records post-enrollment and sample collection in order to monitor medical outcomes. Review of participants' medical records will occur until up to approximately 3,500 subjects have been enrolled and have provided clinical information and a blood sample.

Institution
MUSC
Recruitment Contact
Katherine Taylor
843-792-2297
taylkat@musc.edu

The Watch the Spot Trial Save

Date Added
June 10th, 2016
PRO Number
Pro00044920
Researcher
Gerard Silvestri

List of Studies


Profiles_link
Keywords
Cancer, Lung, Pulmonary
Summary

The study will compare two sets of professionally-recommended guidelines for follow-up of patients with small lung nodules. The two guidelines are different in the frequency and timing of follow-up; one is more frequent and the one is less frequent. All patients who have a small lung nodule detected on a chest scan will have a recommended follow-up schedule automatically inserted into their imaging report so that their health care provider may follow the guideline-recommended intervals for follow-up chest scans. Patients and their physicians may choose not to follow the recommendations, depending on preference or the physician's clinical judgment. As part of this research study, information from patients with a small lung nodule who are seen at MUSC will be collected from the electronic medical record. This will include characteristics of the patient (such as age, smoking history), basic information about the lung nodule (such as nodule size, nodule density), and the medical care received.

Institution
MUSC
Recruitment Contact
Katherine Taylor
843-792-2297
taylkat@musc.edu

"Prognostic markers in postoperative acute kidney injury" Save

Date Added
October 5th, 2009
IRB Number
10497
Researcher
Joshua Lipschutz

List of Studies

Silhouette
Keywords
Cardiovascular, Heart, Kidney
Summary

Kidney failure occurring after heart failure is a serious problem leading to prolonged ICU stay, prolonged hospitalization, dialysis and death. The goal of this study is to identify patients who will develop severe kidney failure after heart surgery. Early identification of patients who will develop kidney failure after surgery will allow earlier and better treatment to prevent this complication. In this study, urine is collected after surgery and analyzed to determine the concentration of many proteins. These proteins are potential biomarkers to predict the development of kidney failure. This is a multi-center study funded by the National Institutes of Health. It is being performed at Duke University, George Washington University and the University of Tennessee. MUSC is the lead center.

Institution
MUSC
Recruitment Contact
Tim Taylor

taylortp@musc.edu

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