NMDA receptor-dependent synaptic plasticity of repetitive transcranial magnetic stimulation (rTMS) after-effects through pharmacologic augmentation. Save

Date Added
February 5th, 2019
PRO Number
Pro00081755
Researcher
Joshua Brown

List of Studies

Keywords
Brain, Healthy Volunteer Studies, Psychiatry
Summary

Transcranial magnetic stimulation (TMS), a non-invasive form of brain stimulation, produces lasting changes in the brain to treat depression and other brain disorders. Emphasis on clinical indications and efficacy has far outpaced a mechanistic understanding of how these changes are produced. In this study, we propose use of the pharmacologic agents d-cycloserine, demonstrated to be safe for human use, to probe in the molecular mechanism of long-term potentiation, the cellular basis of learning and memory. We will measure whether this agent can respectively strengthen the potentiation produced by TMS by looking at the amplitude of motor response (called motor evoked potential or MEP) of the thumb (through electromyography, or EMG).
A better understanding of its mechanism of action promises to optimize our ability to use TMS, and potentially improve duration and degree of response.

Institution
MUSC
Recruitment Contact
Joshua Brown
843-792-3516
brojoshu@musc.edu

Longitudinal Assessment of Financial Burden in Patients with Colon or Rectal Cancer Treated with Curative Intent Save

Date Added
September 6th, 2018
PRO Number
Pro00081552
Researcher
David Marshall

List of Studies


Profiles_link
Keywords
Cancer, Cancer/Gastrointestinal
Summary

Patients will complete questionnaires at 5 time points over 24 months (within 60 days of diagnosis, then at 3, 6, 12 and 24 months after diagnosis). Surveys can be done either on paper or online. It is estimated that it will take 45-60 minutes to complete the first questionnaire and 20-30 minutes to complete the 3, 6, 12 and 24 month questionnaires. Information requested will be about the patient's finances and employment, as well as basic demographic information which will be obtained from the patient's medical records. Patients will be asked to provide their contact information to the ECOG-ACRIN Outcomes and Economics Assessment Unit at Brown University, which will administer the surveys.

Institution
MUSC
Recruitment Contact
Barbara Roe
843-652-1607
broe@tidelandshealth.org

Randomized, Double-Blind, Phase 3B Trial to Evaluate the Safety and Efficacy of 2 Treatment Regimens of Aztreonam 75 mg Powder and Solvent for Nebulizer Solution / Aztreonam for Inhalation Solution (AZLI) in Pediatric Subjects with Cystic Fibrosis (CF) and New Onset Respiratory Tract Pseudomonas aeruginosa (PA) Infection/Colonization Save

Date Added
March 16th, 2018
PRO Number
Pro00072857
Researcher
Daniel e. Brown

List of Studies

Keywords
Cystic Fibrosis
Summary

This is a randomized, double-blind, multi-center study in pediatric
subjects age 3 months to less than 18 years with CF and newly
detected PA respiratory tract colonization/infection. The study
schedule will consist of a minimum of 13 visits: Screening, Day 1
(Baseline and Randomization), Day 29, Weeks 6, 8, 16, and at
12-week intervals thereafter through Week 112. Subjects may be
screened up to 14 days prior to the Baseline visit to determine
eligibility for participation in the study. Screening and Baseline may
occur on the same day for subjects.

Institution
Palmetto
Recruitment Contact
Barbara (Barb) Thompson
803-434-4986
Barbara.Thompson@uscmed.sc.edu

Safety and Efficacy of the Tao Facemask for Positive Pressure Ventilation in the Patients with Significantly Elevated BMIs Save

Date Added
February 20th, 2018
PRO Number
Pro00073465
Researcher
Tod Brown

List of Studies


Profiles_link
Keywords
Surgery
Summary

This study will compare the safety and effectiveness of a new facemask, the Tao mask, as compared to the standard mask for manual ventilation of patients with BMIs of 40 or greater who are undergoing elective surgery. The Tao mask and the standard mask will both be used for each patient but the order of evaluating the masks will be randomized.

Institution
MUSC
Recruitment Contact
Wanda Jones
843-792-1869
joneswr@musc.edu

EEG/fMRI Controlled TMS Real-time Neural Feedback in Anti-Depressive Treatment Save

Date Added
April 7th, 2015
PRO Number
Pro00042072
Researcher
Truman Brown

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies, Mental Health
Summary

This study proposes to design and build a neural imager/stimulator which will let us obtain information about brain circuits and pathways by acquiring electrical and fMRI signals from the brain at the same time. By adding magnetic stimulation to the instrument we will be able to perturb these circuits at precise times and locations in order to both improve how TMS is used as an anti-depression treatment as well as to better understand how our brains function. This research has the potential to revolutionize our understanding of how best to use TMS as a treatment as well as learning how our brains function. This study simply proposes to develop the combined instrument. The use of the new instrument as a anti-depressive treatment will be presented independently after we have developed a working instrument.

Institution
MUSC
Recruitment Contact
Alana McMichael
843-876-2465
EEGTMSproject@musc.edu

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