This study is for adult female patients who have endometrial or cervical cancer that has a high risk of coming back in the pelvis or vagina. The purpose of this study is to test whether the use of a radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can reduce the amount and severity of gastrointestinal side effects (such as diarrhea) that result from radiation, compared with standard radiation techniques. In this study, patients will get either the IMRT or the standard radiation. Patients in group 1 (often called "Arm A"), you will receive IMRT radiation therapy. This radiation technique is not the standard technique in this setting. The radiation therapy will be given once daily, 5 days a week, for 5-6 weeks. The treatment takes about 5-15 minutes each day. Patients may or may not receive weekly IV cisplatin chemotherapy (this will be decided by the study doctor). Patients in group 2 (often called "Arm B"), will receive standard three-dimensional radiation therapy. This is the standard radiation technique in this setting. The radiation therapy will be given once daily, 5 days a week, for 5-6 weeks. The treatment takes about 5-15 minutes each day. Patients may or may not receive weekly IV cisplatin chemotherapy (this will be decided by the study doctor).
This study is for female adult subjects with ovarian cancer. CA125 is a protein (compound made by the body) found in blood that is used to monitor treatments and disease progression in ovarian cancer patients. HE4 is also a protein that is used in the evaluation of ovarian cancer and disease monitoring. Both CA125 and HE4 are approved by the FDA to monitor the treatment of ovarian cancers. The purpose of this study is to investigate HE4 and CA125 expressions in different types of ovarian cancer and to evaluate the changes in HE4 and CA125 before and after treatment. A blood draw of approximately 5mL or 1 teaspoon will be taken from eligible subjects before surgery and before each course of chemotherapy to evaluate HE4 and CA125 expression.
Lesbian and bisexual women under utilize cervical cancer screening programs as compared to heterosexual women. This study uses interviews to explore, identify, and examine the factors that influence cervical cancer screening participation among lesbian and bisexual women. The findings from this study will generate new knowledge and enhance understanding of the cervical cancer screening among lesbian and bisexual women. The findings from this study can be used to design specific interventions to improve cervical cancer screening among lesbian and bisexual women.
Multiple radiation treatments are frequently used to treat pain caused by cancer that has spread to the spine. Image-guided radiosurgery/stereotactic body radiation therapy (SBRT) is a treatment that uses highly focused x-rays to deliver a single high dose on a specific area of the body. Image-guided radiosurgery/SBRT uses special equipment to position the patient and guide the focused beams toward the area to be treated and away from normal tissue.
The purpose of this part of the study is to compare the effects, good and/or bad, of image-guided radiosurgery/SBRT to standard radiation therapy to find out which treatment provides the most rapid pain relief with the least side effects.
This study is for patients that have cervical cancer that has not responded
to prior treatment or has re-grown after prior treatment. The purpose of the first part of this study (called Phase I) is to test the safety and determine the
appropriate dose of ABT-888, given in a capsule form and also known as Velaparib, in combination with receiving cisplatin and paclitaxel intravenously (though a vein). The purpose of the second part of this study is to determine the effectiveness of ABT-888 in combination with intravenous (through the
vein, IV) cisplatin and paclitaxel. We will also be looking at the types and severity of side effects caused by treatment with this drug. ABT-888 inhibits the enzyme Poly ADP ribose polymyerase (PARP), which inhibits DNA repair and may lead to decrease in cancer cell activity. Currently ABT-888 is not FDA approved for treatment of your cancer and is considered experimental.
Participants will be asked to receive IV paclitaxel, IV cisplatin and take ABT-888 as long as there is evidence that the tumor is not growing and the participant is not experiencing any unacceptable side effects.
After participants are finished with this treatment, the study doctor will ask them to visit the office for follow-up exams every three months for the first two years and then every six months for the next three years after completion of their treatment with paclitaxel, cisplatin and ABT-888.
The purpose of this study is to determine the effectiveness of Trametinib alone or in combination with GSK2141795 in treating recurrent or persistent endometrial cancer and to determine the types and severity of side effects caused by treatment with these drugs.
Trametinib and GSK2141795 are both experimental drugs. Experimental means that the drug is currently being tested and is not approved for sale in the United States by the Food and Drug Administration (FDA) or similar regulatory agencies in foreign countries. These drugs are being evaluated in endometrial cancer because they act in ways which are thought to be important in the growth and survival of endometrial cancer.
This phase II trial studies how well dasatinib works in treating patients with persistent ovarian, fallopian tube, endometrial, or peritoneal cancer. Dasatinib may shrink patients' tumors by blocking some of the enzymes needed for cell growth.
The purpose of this study is to find out if providing patients with educational materials helps them to be better prepared for making a decision about participating in a research study to treat their cancer.
This study is for adult women who have advanced or recurrent endometrial (uterine) cancer. The purpose is to find out if the drug combination of paclitaxel, carboplatin and metformin works better than paclitaxel and carboplatin alone in treating uterine cancer.