All primary total knee replacement patients will undergo the surgical procedure per the surgeon's standard technique. Samples of tissue that is ordinarily removed and discarded as a part of the procedure will be sent to the pathology lab, where the pathologist will prepare and stain the tissue sample to assess for levels of a specific protein thought to be a marker for the likelihood of the soft tissues to form dense versus loose scar tissue. We will then follow each patient's postoperative course to determine if levels of the protein in question, alpha smooth muscle actin (ASMA) correlate with outcomes. Outcomes will include postoperative pain, range of motion, as well as patient-reported satisfaction and function scores.
Low vitamin d levels are common among patients undergoing orthopedic surgery. However, very little is known about how vitamin d affects outcomes in patients undergoing total joint replacement surgery. Our study will look at how common low vitamin d status is among patients undergoing total hip and total knee replacement surgery. We will also look at how vitamin d levels affect complication rates and hospital readmission rates.
Outcomes after anterior spine surgeries are mostly satisfactory, with an extremely low mortality rate. However, there are inherent morbidities, perhaps the most notable of these is injury to the recurrent laryngeal nerve, which can significantly influence patients' quality of life. One method to potentially reduce this is the use of intraoperative monitoring of the recurrent laryngeal nerve during surgery. The central goal of this study is to determine the effectiveness of recurrent laryngeal nerve intraoperative monitoring to reduce the risk of adverse voice outcomes following anterior cervical spine surgeries. Patients will undergo routine ACDF surgery by MUSC spine surgeons, with use of intraoperative neuro-monitoring of the recurrent laryngeal nerve via EMG endotracheal tube. Pre-operative and post-operative swallowing, voice, and overall quality of life standardized questionnaires will be administered, and outcomes evaluated and analyzed.