The Role of Vitamin D in Mitigating COVID-19 Infection Severity: Focusing on Reducing Health Disparities in South Carolina

Date Added
June 2nd, 2020
PRO Number
Pro00099939
Researcher
Carol Wagner

List of Studies

Keywords
Coronavirus, Vitamin D
Summary

Participants who test positive for COVID-19 at MUSC/affiliate virtual care testing venues, but who do not require hospitalization, will be approached to be randomized to a placebo or a bolus of oral vitD3 (20,000 IUX3d) followed by 6000 IU vitD3/day for 12 months. All participants will receive a multivitamin containing 800 IU vitD3. Study groups will be compared on the basis of 25(OH)D concentration and subsequent COVID-19, symptom severity, need and duration of hospitalization (LOS), admission to the ICU, ventilatory support, and mortality, return to usual daily activities and/or work, as a function of age, BMI, and other recognized COVID-19 risk factors.

Participants who test negative for COVID-19 at MUSC/affiliate virtual care testing venues, will be approached to be randomized to a placebo or 6000 IU vitD3/day for 12 months. All participants will receive a multivitamin containing 800 IU vitD3. Study groups will be compared on the basis of 25(OH)D concentration, COVID-19 antibody titers, and the number who become COVID-19 positive during the course of the study, as well as severity of illness using validated symptom questionnaires, need for hospitalization, duration of acute symptoms, return to typical daily activities and/or work.

The protocol is for the full study, with numbers of participants for this pilot in parentheses. We have funding for the pilot with the UDAK in this application. We are continuing to search for funding for the full study, and the science is powered for the full study. When we receive funding for the full study, we will submit an amendment to increase the intended participant numbers.

Institution
MUSC
Recruitment Contact
Judith Shary
8437928454
sharyj@musc.edu

A Phase 2b, Multicenter, Randomized, Open-label, Controlled, 3-Arm Study to Evaluate the Clinical Efficacy and Safety of SHP607 in Preventing Chronic Lung Disease Through 12 Months Corrected Age Compared to Standard Neonatal Care in Extremely Premature Infants

Date Added
December 10th, 2019
PRO Number
Pro00091762
Researcher
Carol Wagner

List of Studies

Keywords
Children's Health, Infant, Pediatrics
Summary

Babies that are born extremely prematurely are at higher risk of developing chronic (long term) lung disease (CLD) and other complications (problems). The purpose of this study is to test the safety and effectiveness of an investigational drug called mecasermin rinfabate (rhIGF-1/rhIGTBP-3) or SHP607. The researchers want to find out if SHP607 can help reduce the risk of chronic lung disease in babies born prematurely and if it can help reduce the risk of other complications.

Institution
MUSC
Recruitment Contact
Della MacNicholas
843-792-8385
macnichd@musc.edu

Maternal vs. Direct Infant Vitamin D Supplementation during Lactation RCT: Priming the Infant Immune System: Pilot Study

Date Added
January 5th, 2016
PRO Number
Pro00050609
Researcher
Carol Wagner

List of Studies

Keywords
Lactation, Vitamin D
Summary

Breastfeeding is important for the development of the immune system of the infant. Emerging data suggest that vitamin D plays an important role in immunity as well. Exclusively breastfeeding mothers and their infants will be studied in a 3-month (4-study visit) pilot study of vitamin D supplementation versus placebo. Longitudinal effects of vitamin D status on breast milk composition and on the infant's immune system will be examined.
Additionally, exclusively breastfeeding mothers who are currently on vitamin D supplementation will be studied at a single visit, at which mothers will provide a single breastmilk sample and have a single blood sample obtained. These samples will be used to examine effects of vitamin D supplementation on breast milk composition.

Institution
MUSC
Recruitment Contact
Renee Washington
843-792-5884
washinro@musc.edu



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