Gastroparesis is a condition in which the stomach empties food more slowly than normal, causing symptoms such as nausea, vomiting, bloating, abdominal pain, and poor quality of life. This study seeks to understand how certain immune cells in the stomach and intestines, called macrophages, may contribute to these symptoms when they become inflamed or function abnormally. Researchers believe that a naturally occurring molecule called miR-10b helps keep these immune cells healthy and balanced. When miR-10b levels are low, inflammation may increase, leading to problems with stomach movement and weakening of the intestinal barrier.
To investigate this, researchers will analyze stomach and small intestine biopsy samples from people with diabetic gastroparesis, idiopathic gastroparesis, and individuals without the condition. The study will compare immune cell activity, inflammation levels, and tissue health between these groups. Findings from this research may identify new biological markers of gastroparesis and support the development of treatments that target the underlying causes of the disease rather than only managing symptoms.