The purpose of this study is to find out more information about the study drug iloprost for the treatment of symptomatic Raynaud's phenomenon (RP) attacks in people with scleroderma. A Raynaud's attack is defined as one where you notice at least one color change of your finger(s) (blue, white, or red) associated with at least one symptom (pain, numbness, tingling, and/or discomfort of the finger[s]). Your participation in this study will last approximately 9 weeks and will include 8 visits to the study center and 1 phone call from the study staff.
The purpose of this study is to understand how different types of e-cigarettes affect the way smokers use tobacco products. Participants will complete three in-person visits. Prior to the second visit, they will be required not to smoke after midnight on the night before the visit. At this visit, the participant will try two e-cigarette e-liquids or one other tobacco product, called a heated tobacco product. Participants have a 75% chance of being assigned to try the two e-liquids and a 25% chance of being assigned to try the heated tobacco product. They will complete a task where they will choose between the product(s) they sampled, a cigarette, or nothing. Then they will receive one of these products to take home for one week. We are interested in how the product the participants are given changes their tobacco use. After they leave the visit, they are not required to use the product and it is entirely up to them if and how they use it. Participants will complete three study visits, and daily electronic diaries across the two weeks of the study. Participation will last approximately two weeks. Both e-cigarettes and heated tobacco products are likely less harmful than combustible cigarettes, but we are unsure how harmful, or how safe they might be. Side effects from using the e-cigarette/heated tobacco product are generally rare and mild, and may include: nausea, headache, heartburn, irritability, anxiety, headache, cough, or trouble sleeping. There is no direct benefit for participating. Participation will aid researchers to determine how different types of tobacco products affect smoking behavior.
The goal of this research is to understand how different types of e-cigarettes affect tobacco use. Participants will either be assigned to a control group that does not receive an e-cigarette or be assigned to receive one of two different types of e-cigarettes to sample in the lab and at home. We will measure participants' smoking and smoke exposure during the study.
The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes. Participants will receive an e-cigarette to sample over a three week period. During this time period they will complete daily electronic diaries and weekly lab visits. The results from this information will help us understand how different types of e-cigarettes are likely to influence cigarette and e-cigarette use.
Sickle cell disease (SCD) is a genetic blood disorder present at birth characterized by painful vaso-occlusive episodes. Pain episodes typically result in approximately one to two severe pain crises requiring hospitalization per year along with another ten pain episodes managed at home. Pain crises can emerge as early as six to twelve months and most children with the most common form of the disease (HbSS), experience a pain episode requiring hospital care by the age of five years. Promoting better coping with pain in preschool age children likely requires additional adaptation of methods and consideration of a developmental framework. Very young children have limited coping skills, a limited ability to communicate pain, and it is up to the primary caregiver to correctly interpret and treat the pain that a child may be experiencing. Despite the frequency of painful episodes early in life in SCD, there has been little work to-date addressing pain management in young children with SCD. Management of pain episodes early in life by parents may be an important developmental context for later child and family coping with pain, as well as coping with other aspects of this chronic health condition. Consequently, the current study will target parents of preschool age children with SCD through an online video-based platform in order to teach pain management skills to help to identify and manage SCD-related pain episodes.