A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study Evaluating the Safety and Efficacy of Intravenous Iloprost in Subjects With Systemic Sclerosis Experiencing Symptomatic Digital Ischemic Episodes (AURORA Study) Save

Date Added
November 12th, 2019
PRO Number
Pro00092860
Researcher
Edwin Smith

List of Studies


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Keywords
Autoimmune disease, Drug Studies, Immune System, Rare Diseases, Scleroderma, Stage III
Summary

The purpose of this study is to find out more information about the study drug iloprost for the treatment of symptomatic Raynaud's phenomenon (RP) attacks in people with scleroderma. A Raynaud's attack is defined as one where you notice at least one color change of your finger(s) (blue, white, or red) associated with at least one symptom (pain, numbness, tingling, and/or discomfort of the finger[s]). Your participation in this study will last approximately 9 weeks and will include 8 visits to the study center and 1 phone call from the study staff.

Institution
MUSC
Recruitment Contact
Nathan Wilson
843-792-8613
wilsonn@musc.edu

Impact of Non-Cigarette Tobacco Product Formulation on Reinforcement Value and Use in Current Smokers Save

Date Added
November 5th, 2019
PRO Number
Pro00093724
Researcher
Tracy Smith

List of Studies

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Keywords
Smoking
Summary

The purpose of this study is to understand how different types of e-cigarettes affect the way smokers use tobacco products. Participants will complete three in-person visits. Prior to the second visit, they will be required not to smoke after midnight on the night before the visit. At this visit, the participant will try two e-cigarette e-liquids or one other tobacco product, called a heated tobacco product. Participants have a 75% chance of being assigned to try the two e-liquids and a 25% chance of being assigned to try the heated tobacco product. They will complete a task where they will choose between the product(s) they sampled, a cigarette, or nothing. Then they will receive one of these products to take home for one week. We are interested in how the product the participants are given changes their tobacco use. After they leave the visit, they are not required to use the product and it is entirely up to them if and how they use it. Participants will complete three study visits, and daily electronic diaries across the two weeks of the study. Participation will last approximately two weeks. Both e-cigarettes and heated tobacco products are likely less harmful than combustible cigarettes, but we are unsure how harmful, or how safe they might be. Side effects from using the e-cigarette/heated tobacco product are generally rare and mild, and may include: nausea, headache, heartburn, irritability, anxiety, headache, cough, or trouble sleeping. There is no direct benefit for participating. Participation will aid researchers to determine how different types of tobacco products affect smoking behavior.

Institution
MUSC
Recruitment Contact
Tracy Smith
8437925164
smithtra@musc.edu

Comparison of leading e-cigarette product types on relative reinforcement value and tobacco use patterns among current smokers Save

Date Added
July 2nd, 2019
PRO Number
Pro00089701
Researcher
Tracy Smith

List of Studies

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Keywords
Smoking
Summary

The goal of this research is to understand how different types of e-cigarettes affect tobacco use. Participants will either be assigned to a control group that does not receive an e-cigarette or be assigned to receive one of two different types of e-cigarettes to sample in the lab and at home. We will measure participants' smoking and smoke exposure during the study.

Institution
MUSC
Recruitment Contact
Tracy Smith
8437925164
smithtra@musc.edu

Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokers Save

Date Added
September 4th, 2018
PRO Number
Pro00081069
Researcher
Tracy Smith

List of Studies

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Keywords
Smoking
Summary

The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes. Participants will receive an e-cigarette to sample over a three week period. During this time period they will complete daily electronic diaries and weekly lab visits. The results from this information will help us understand how different types of e-cigarettes are likely to influence cigarette and e-cigarette use.

Institution
MUSC
Recruitment Contact
Tracy Smith
8437925164
smithtra@musc.edu

Online Pain Management Program for Parents of Preschool-Age Children with Sickle Cell Disease: A Pilot Study Save

Date Added
December 1st, 2016
PRO Number
Pro00055478
Researcher
Jeffrey Schatz

List of Studies

Keywords
Blood Disorders, Pain
Summary

Sickle cell disease (SCD) is a genetic blood disorder present at birth characterized by painful vaso-occlusive episodes. Pain episodes typically result in approximately one to two severe pain crises requiring hospitalization per year along with another ten pain episodes managed at home. Pain crises can emerge as early as six to twelve months and most children with the most common form of the disease (HbSS), experience a pain episode requiring hospital care by the age of five years. Promoting better coping with pain in preschool age children likely requires additional adaptation of methods and consideration of a developmental framework. Very young children have limited coping skills, a limited ability to communicate pain, and it is up to the primary caregiver to correctly interpret and treat the pain that a child may be experiencing. Despite the frequency of painful episodes early in life in SCD, there has been little work to-date addressing pain management in young children with SCD. Management of pain episodes early in life by parents may be an important developmental context for later child and family coping with pain, as well as coping with other aspects of this chronic health condition. Consequently, the current study will target parents of preschool age children with SCD through an online video-based platform in order to teach pain management skills to help to identify and manage SCD-related pain episodes.

Institution
Palmetto
Recruitment Contact
Kelsey Smith
803-563-7931
smithk88@email.sc.edu

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