Existence of hematopoietic stem cells-derived cells in human periodontal ligament and alveolar bone. Save

Date Added
May 31st, 2016
PRO Number
Meenal Mehrotra

Dental, Periodontal Disease

Periodontitis is a major cause of irreversible destruction of tissues leading to a loss of attachment between teeth and their supporting tissues. Several strategies are being tested experimentally to enhance periodontal regeneration, one of them being the use of stem cells.
In this study, eligible participants that are patients of the James B. Edwards College of Dental Medicine scheduled to have their teeth extracted. The teeth being extracted from patients during oral surgery, which otherwise would be discarded, will be donated for laboratory tests.

Recruitment Contact
Lynn West

PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke Save

Date Added
July 21st, 2015
PRO Number
Souvik Sen
Periodontal Disease, Stroke, Vascular

The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic stroke and TIA survivors. The study uses the resources in both states including established
dental centers, Joint Commission Certified Stroke Centers, the Schools of Public Health, and the Institute for Partnerships to Eliminate Health Disparities. The proposal addresses specific issues with regards to recruitment of African-American and rural stroke/TIA patients advocating the use of culturally appropriate strategies to educate the study subjects regarding stroke, periodontal disease and the periodontal stroke link.
The study proposes to utilize economic evaluation of the periodontal intervention from the budgetary
perspective. The focus will be on the financial sustainability of providing aggressive periodontal therapy (with
certain, although relatively low expenditures) in exchange for a reduction of uncertain recurrent vascular events
that may require high cost emergency department utilization and/or inpatient care. The sustainability of the
proposed intervention after the completion of the project is integrally linked to the health economic assessment
to show the health care cost savings. By integration with a rural primary care center, with an African American
majority and households with average incomes below the state average, the study ensures that the proposed
intervention to reduce stroke disparity is applicable to this target population.

Recruitment Contact
Lauren Giamberardino


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