The purpose of this research study is to review the effectiveness and safety of PR610, including the dose level and side effects, for the treatment of adults diagnosed with non-squamous, nonsmall cell lung cancer (NSCLC).

This is a clinical research study of a blood test made by the sponsor,Integrated Diagnostics, Inc., to guide the decision-making of patients with lung nodules and their doctors. This study aims to determine whether one or more proteins in the blood is associated with a stable CT-detected lung nodule. Blood samples are obtained when subjects enroll in the study, one year after enrollment, and two years after enrollment.

The purpose of this research study is to review the effectiveness and safety of necitumumab in combination with chemotherapy vs chemotherapy alone in adults diagnosed with Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC).

The purpose of this study is to find out the best maintenance therapy for patients with advanced stage non-small cell lung cancer. Maintenance therapy is usually given after 4 cycles of standard chemotherapy (1 cycle = 21 days) to keep the disease under control for a longer duration. This study will compare the effects, good and/or bad, of bevacizumab, pemetrexed or the combination of the two agents when given as maintenance therapy.

This randomized phase II clinical trial is studying Manuka honey to see how well it works in preventing esophagitis-related pain in patients receiving chemotherapy and radiation therapy for lung cancer.

Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed disodium may stop the growth of tumor cells by blocking some enzymes needed for cell growth. It is not yet known whether giving bevacizumab or pemetrexed disodium alone or in combination is more effective in treating non-squamous non-small cell lung cancer.

This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer.

Radiation therapy uses high energy x-rays to kill tumor cells. This may be an effective treatment for extensive stage small cell lung cancer.

This randomized phase II trial is comparing how well radiation therapy to the brain works when given with or without radiation therapy to other areas of the body in treating patients with extensive stage small cell lung cancer.

The goal of this study is to help researchers learn better ways to coordinate patients’ care between physician specialists, nurses, social workers and other care providers—called multidisciplinary care (MDC). The assumed benefits of MDC include improved satisfaction for stakeholders such as better informed and satisfied patients and physicians, streamlined care coordination and decision-making across multiple physician specialists, and a greater ability to evaluate patients for enrollment into clinical trials.

Subjects will be asked to allow researchers to look at their medical records and record some information including race/ethnicity, age, clinical diagnosis, tumor grade, and other health conditions, such as high blood pressure and treatment history. Subjects may also be asked to complete a survey about their cancer care.

The purpose of this research study is to understand how programs to help smokers quit may impact people with cancer who are interested in quitting smoking. We want to learn about the effects of receiving smoking cessation programs on you and your health. We will also assess the ease of delivering a Quitline based smoking cessation intervention to cancer patients in an outpatient setting.

This is a clinical research study of a blood test made by the sponsor,Integrated Diagnostics, Inc., to guide the decision-making of patients with lung nodules and their doctors. This study aims to determine whether one or more proteins in the blood is associated with a stable CT-detected lung nodule. Blood samples are obtained when subjects enroll in the study, one year after enrollment, and two years after enrollment.