The purpose of this study is to collect blood specimens and determine the levels of natriuretic peptides in the blood in patients that are presenting with a suspicion of new onset or worsening symptoms of heart failure. Blood specimens collected during this study will be used to support expanded development of a blood test that can help physicians diagnose heart failure.

The blood test (Access BNP Assay) being developed will measure natriuretic peptides that are released into the blood when the heart muscle is stretched and working too hard. This information is being used to develop a better blood test(s).

If a person has symptoms of an upper respiratory infection, the sponsor is developing a blood test to help decide if it is bacterial or viral infection. Using a blood sample, the test will give a score of 0-100 to help decide along with your symptoms if antibiotics are necessary for treatment.

Substudy: Subjects with suspected infection will give a blood sample for the evaluation of certain biomarkers to help determine if the biomarkers can predict the disease progression to severe disease.

If a person has symptoms of an upper respiratory infection, the sponsor is developing a blood test to help decide if it is bacterial or viral infection. Using a blood sample, the test will give a score of 0-100 to help decide along with your symptoms if antibiotics are necessary for treatment.

Substudy: Subjects with suspected infection will give a blood sample for the evaluation of certain biomarkers to help determine if the biomarkers can predict the disease progression to severe disease.