IDENTIFICATION OF ACCESSIBLE CHROMATIN MARKS IN ACTIVATED DENDRITIC CELLS FROM FEMALE AND MALE SLE PATIENTS Save

Date Added
November 16th, 2017
PRO Number
Pro00069599
Researcher
Melissa Cunningham

Silhouette
Keywords
Autoimmune disease
Summary

Systemic lupus erythematosus (SLE, lupus) is an autoimmune disorder characterized by dysregulated immune responses and subsequent production of autoantibodies. In recent years, data suggests that changes in certain kinds of immune cells, dendritic cells, affect development of lupus.

Institution
MUSC
Recruitment Contact
John LeMay
843-792-5824
lemay@musc.edu

A Randomized, Controlled Double-blind Study Comparing the Efficacy and Safety of Orelvo (Voclosporin) (23.7 mg Twice Daily) with Placebo in Achieving Renal Response in Subjects with Active Lupus Nephritis Save

Date Added
September 26th, 2017
PRO Number
Pro00069657
Researcher
Melissa Cunningham

Silhouette
Keywords
Autoimmune disease, Lupus
Summary

The primary objective of the study is to assess whether Orelvo, added to the standard of care treatment for patients with Lupus Nephritis, is able to reduce disease activity. The study will last for about 1 years and will involve 16 study visits. Patients who meet criteria will be assigned to one of two groups: One group will receive Orelvo 23.7mg taken twice a day by mouth, and the other will receive placebo. The study is blinded, with means neither the patient nor the study doctor will know what group subjects are in. Patients will be followed closely by the study doctors to determine their lupus activity levels over the course of 1 year.

Institution
MUSC
Recruitment Contact
Margaret Lindemuth
843-792-8613
hardinm@musc.edu

Identification of Dysregulated IFN Pathways in SLE Save

Date Added
August 12th, 2014
PRO Number
Pro00036195
Researcher
Melissa Cunningham

Silhouette
Keywords
Autoimmune disease, Healthy Volunteer Studies, Lupus
Summary

This study will feature a one time visit, for both subjects with lupus. Blood samples, brief medical exam, medical history and skin tissue acquisition will be performed on all subjects. Qualifying subjects will be compensated for their time and effort.

Institution
MUSC
Recruitment Contact
John LeMay
843-792-5824
lemay@musc.edu

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