The CRISIS2 trial will study out-patients (non-hospitalized patients) who have a
positive SARS-CoV-2 test and are symptomatic. Subjects will be randomized to
receive standard of care (SOC) + 5 days of brequinar or SOC + 5 days of placebo.
The purpose of this study is to determine if the in vitro antiviral activity of
brequinar can be duplicated in patients infected with SARS-CoV-2 by measuring
the effect of brequinar on viral shedding. Importantly, the safety and tolerability of
brequinar will also be determined in these patients. The results of this proof-of concept study will inform future studies that will help determine if brequinar is a
safe and effective drug for the treatment of SARS-CoV-2 infection.