The proposed study will employ treatment-seeking AUD individuals who will be randomly assigned to receive either 15 mg of rapamycin (sirolimus) or placebo immediately after the first of two alcohol cue exposure sessions scheduled to occur on consecutive days. Subjective responses (i.e., craving) and physiological (heart rate & skin conductance) reactivity will be obtained before, during and after cue presentations in both sessions. The durability of any observed treatment effects will be assessed in a Follow-up session performed approximately 10 days following completion of the second session. Treatment effects on self-report measures of drinking behavior during the approximately 10 days preceding the Follow-up session will also be assessed.
The goal of this study is to improve rates of lung-directed therapy with curative intent (LDTCI) among African Americans with probable or proven early stage non-small cell lung cancer via a patient navigation intervention. Study participants will be recruited from study sites across the southern US, including the Medical University of South Carolina Hollings Cancer Center (MUSC HCC) and the Comprehensive Cancer Center of Wake Forest NCORP Research Base (WF NCORP RB) and its affiliated sites. Participants will be randomized by study site. This study does not include blood draws or therapeutic interventions. During the one-year follow-up period, each participant will complete 5 telephone surveys.
Exercise adoption enhances well-being and recovery from breast cancer. In two previous studies, we have trained community volunteers with the American Cancer Society to provide exercise counseling for breast cancer survivors and the survivors increased their exercise in the short-term (R01 CA132854). This randomized controlled study examines the effects of three maintenance conditions following the 3-month exercise counseling provided by the community volunteers on exercise participation among breast cancer patients at longer follow-ups.
To begin, all study participants (n=150) will receive a 3-month telephone-based exercise program from Reach to Recovery (RTR) volunteers at the American Cancer Society. This will be followed by three maintenance programs during Months 4-9: Reach Plus (participants will receive exercise logs and feedback reports), Reach Plus Phone (monthly counseling calls from coaches, exercise logs and feedback reports) and 3) Reach Plus Messages (monthly email/text messages, exercise logs and feedback reports).
We will enroll 150 women who have completed treatment for breast cancer and assess their exercise behavior, fatigue, quality of life, and mood at baseline (before the 3 month exercise program), 3, 6, 9 and 12 months. The costs and effectiveness of the three groups will be examined to help guide future dissemination of this peer mentoring approach in community-based organizations to enhance cancer survivorship.