This study will use neuroimaging to understand how the connections in the brain change in Alzheimer's Disease. Changes will also be examined in individuals with mild cognitive impairment and healthy aging. The goal is to discover which brain changes are present in healthy aging and MCI so that future studies can assess the risk for developing Alzheimer's Disease. The study involves blood draw, cognitive testing, MRI, PET scanning, and a 1-year follow-up visit to repeat cognitive testing and MRI scanning.
Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 30 and 65.
The spread of emerging infectious diseases represents a threat to mankind from either nature or bioterrorism. Given the enormous threats, there are many strategies to prevent and treat the next pandemic. Fundamental to all is containment, and this requires protection of HCWs first exposed to and who treat the patients. SimTunes, LLC was launched by MUSC to develop and sell healthcare worker (HCW) simulation educational materials. This study will investigate an educational product created by SimTunes, called Medical Unit Specialized Simulation Training, that will keep healthcare workers prepared for and safe in the next lethal pandemic. The research will test MUSST's superiority over conventional educational methods and its ability to be used in community hospitals and with a new disease.
Alcohol Use Disorder (AUD) is a risk factor for Alzheimer's Disease (AD), but more research is needed to identify the potential mechanisms underlying this risk. The present study will use fMRI to examine brain network profiles in mid-life AUD. The goal is to develop techniques to assess risk for Alzheimer's Disease and related dementias. Participation includes cognitive testing and MRI scanning.