A 95-week study comparing the efficacy and safety of a specific dose of a trial product named zenagamtide versus two different doses of semaglutide, administered once weekly via injection along with a reduced-calorie diet and increased physical activity on weight management in participants with obesity.

An 87-week clinical research study comparing zenagamtide in doses of 6mg, 12mg, 25mg, 50 mg or 2 x 50mg versus placebo, all administered as once-daily oral tablets as an adjunct to a reduced-calorie diet and increased physical activity, in participants with obesity.

A 144-week clinical research study to look at how well an investigational obesity medicine works, along with a reduced-calorie diet and increased physical activity in participants with obesity.
The medicines are injected subcutaneously (under the skin) once a week.
This study also includes a placebo.