Localizing Epileptic Networks using 3T MRI

Date Added
September 29th, 2020
PRO Number
Pro00102615
Researcher
Leonardo Bonilha

List of Studies


Keywords
Epilepsy
Summary

The purpose of this research study is to study the capabilities of new methods for studying the brain using Magnetic Resonance Imaging (MRI). MRI already provides detailed images of brain anatomy, but newer methods including new MRI techniques and magnetic resonance spectroscopy expand this capability. These new MRI methods will not require any invasive procedures. If successful, these new methods will expand the information, which can be obtained from MRI studies of the brain in patients with epilepsy.

Institution
MUSC
Recruitment Contact
Lindsey Weissman
843-792-2330
weissmal@musc.edu

Speech entrainment for Aphasia Recovery

Date Added
January 6th, 2020
PRO Number
Pro00091924
Researcher
Leonardo Bonilha

List of Studies


Keywords
Language, Speech Disorders, Stroke, Stroke Recovery
Summary

After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced speech production, with the speaker producing only a few words or even less. Speech entrainment therapy (SET) is a treatment that has been shown to increase fluency in people with non-fluent aphasia. Our study looks to define the best dose of SET that leads to sustained improvements in spontaneous speech production.
Participants who are eligible will undergo baseline language testing, an MRI, and will be randomized into one of 4 treatment groups: SET for 3 weeks, SET for 4.5 weeks, SET for 6 weeks, and no treatment (control group).

Institution
MUSC
Recruitment Contact
Anna Doyle
843-792-3678
doylean@musc.edu

Center for the Study of Aphasia Recovery (C-STAR) - Project 1 (POLAR) Project 001: Modeling Treated Recovery from Aphasia

Date Added
November 9th, 2016
PRO Number
Pro00058579
Researcher
Leonardo Bonilha

List of Studies


Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Speech and language therapy for the management of aphasia (a language impairment that often occurs as a result of a stroke) is generally shown to be effective. However, the reasons that certain treatments may work for some individuals, and not others, and why some individuals do not respond to treatment is largely unknown. In this study, we plan to identify and model the relationship between many different factors (such as personal/biographical factors and an individual's baseline cognitive and language abilities) to help predict aphasia treatment outcome. Participants will be recruited for speech and language testing, brain imaging (MRI), and aphasia treatment (as warranted).

Institution
MUSC
Recruitment Contact
Anna Doyle
843-792-3678
doylean@musc.edu



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