The purpose of this study is to evaluate the potential usefulness of pamrevlumab in IPF, compared to placebo (a substance that looks like the investigational drug, but has no active agent). The total duration of your involvement on the study will be approximately 60 weeks. If you meet the entry criteria (requirements) and decide to participate in this study, you will be randomly assigned to 1 of 2 treatment groups: Arm A: Pamrevlumab or Arm B: Placebo. The study includes clinical visits. Approximately 565 subjects will participate in this study at approximately 200 research sites globally.

This will be a Phase I, double-blind, randomized, placebo-controlled study conducted in 2 parts, single and multiple inhaled dose, at multiple sites. The purpose of this study is to find out about the safety and tolerability of TRK-250 after single and multiple inhaled doses in subjects with idiopathic pulmonary fibrosis (IPF). TRK-250 is an experimental drug which is not approved by the United States Food and Drug Administration (FDA) for the treatment of idiopathic pulmonary fibrosis. This study will be the first time that TRK-250 is administered to humans. This study will be conducted in 2 parts, single inhaled dose (Part A) and multiple
inhaled doses (Part B). Part A of this study will have 6 study visits over a period of up to no more than 9 weeks. Part B of this study will have 7 study visits over a period of 10 weeks.

The purpose of this study is to evaluate the safety of the study drug ND-L02-s0201 when administered at two dose levels compared with placebo (A placebo looks like the study drug, but the injection does not contain the active ingredient in ND-L02-s0201) to help with IPF. ND-L02-s0201 is being developed to treat fibrosis (scarring) of the lungs. ND-L02-s0201 is made up of tiny particles of fat that contain modified vitamin A and help carry the drug through the body and to reach special cells in the lung. It is hoped that the study drug will slow the progression of fibrosis in your lungs. You will be involved in the study for up to 40 weeks (about 10 months).