Neurocircuit Strategy to Decrease Cocaine Cue Reactivity

Date Added
September 17th, 2019
PRO Number
Hesheng Liu

List of Studies

Drug Studies

The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) with or without N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine images. Participants (N=144) will undergo a baseline MRI visit to assess craving and brain function, and then be randomized to one of four conditions: 1) NAC + Active TBS, 2) NAC + Sham TBS, 3) Placebo + Active TBS, 4) Placebo + Sham TBS. In addition, a subset of individuals will be assigned to one of two groups that will not receive any study medication but will be randomly assigned to receive either: Active TBS alone or Sham TBS alone. Following 3-days of study medication (NAC or Placebo), or within at least 24 hours for the no study medication groups, participants will return for a second MRI visit wherein brain function and cravings will be assessed immediately before and after active TBS or SHAM TBS. Participants will be contacted via phone over the following 3-weeks to assess mood and craving.

Recruitment Contact
Catherine Hubbard

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