Epithelial ovarian cancer (EOC) is the 5th leading cause of cancer death in women in the U.S. African-American (AA) women have the lowest survival of any racial/ethnic group,1 yet little is known about factors affecting survival among AAs. The African American Cancer Epidemiology Study (AACES) is a multi-site epidemiologic study of AA women in diverse geographic regions. AACES has enrolled an unprecedented number of AA participants during a previous funding period, 593 AA women with invasive EOC and 752 controls, making AACES the largest study of ovarian cancer in AA women to date. Prior to AACES, no epidemiologic study of ovarian cancer had enrolled more than 150 AA cases and 150 AA controls. Due to comprehensive data collection, pathology assessment and length of follow-up, AACES is uniquely positioned to evaluate factors influencing the survival of EOC in AA women. The causes of the poor outcomes in AA women are likely multifactorial and need to be examined from multiple levels, including factors affecting both the neighborhood social environment and individual level factors.