Treatment of Drug-resistant Adult and Pediatric Primary Focal Segmental Glomerulosclerosis Using the Liposorber® LA-15 System Save

Date Added
November 26th, 2019
PRO Number
Pro00089025
Researcher
Milos Budisavljevic

List of Studies


Profiles_link
Keywords
Blood Disorders, Kidney
Summary

A device called the "Liposorber LA-15 System" has been approved by the
United States Food and Drug Administration for treating kids with focal
segmental glomerulosclerosis (FSGS). The "Liposorber LA-15 System" can only be used if other treatment options, like drugs, don't work or can't be used,
but the kidneys are still working okay. It can also be used if the subject
has had a kidney transplant and the FSGS comes back after the
transplant. Although the Liposorber System can be used for FSGS, we
are not sure how well the Liposorber System works. So, we are doing this
study to find out how well the treatment works in adults.
In this research study, there will be up to 5 adults who have FSGS
enrolled at MUSC. Subjects will come back for up to 12 treatments over 9
weeks and then 5 visits to their study doctor over the next 2 years.

Institution
MUSC
Recruitment Contact
Linda Walker
843-792-6109
walkerlp@musc.edu

CureGN: Cure Glomerulonephropathy Save

Date Added
February 20th, 2018
PRO Number
Pro00072900
Researcher
Milos Budisavljevic

List of Studies


Profiles_link
Keywords
Kidney
Summary

If you have a glomerular disease, have had kidney biopsy in the last 5 years, are not on dialysis, and have not had a kidney transplant or was previously enrolled in the NEPTUNE study, you may be eligible to take part in this research study. The purpose of this study is to gather a group of patients with glomerular disease to create a source of information along with your kidney biopsy slides, blood, and urine samples so that researchers can easily and effectively study glomerular disease.

Institution
MUSC
Recruitment Contact
Linda Walker
843-792-6109
walkerlp@musc.edu

Identification and characterization of "permeability factor" in blood of patients with proteinuric kidney diseases Save

Date Added
January 2nd, 2013
PRO Number
Pro00018380
Researcher
Milos Budisavljevic

List of Studies


Profiles_link
Keywords
Kidney
Summary

Overwhelming evidence exists that some types of proteinuric kidney diseases are caused by factor(s) present in patients' blood. Identification and characterization of such factor(s) would greatly help in better and noninvasive diagnosis of such conditions, development of better therapeutic options and potentially reveal underlying pathogenic mechanisms.
Owing to tremendous capabilities of proteomics facility within the Division of Nephrology we developed experiments that we think will result in significant improvement in our knowledge of major kidney diseases.

Institution
MUSC
Recruitment Contact
Linda Walker
(843) 792-6109
walkerlp@musc.edu

The POSEIDON Kidney Disease Registry and Biobank Save

Date Added
September 18th, 2012
PRO Number
Pro00019764
Researcher
Joshua Lipschutz

List of Studies

Silhouette
Keywords
Kidney, Rare Diseases, Transplant, Urinary
Summary

Currently, kidney disease affects up to 20% of the US population and is a strong contributor to morbidity and mortality in these patients. Specific therapies and diagnostic tools for kidney disease have been very slow to develop because of the absence of high quality samples and data that can be used for research studies. The purpose of this study is to develop a registry and sample bank called Poseidon (Prevention, Optimizing Safety, Early Intervention and DetectiOn in Nephrology) biobank that can be used for future research. In this study, patients can consent to donating their residual kidney tissue if they undergo a kidney biopsy and blood or urine during routine clinical care procedures. We will also collect blood and urine outside of clinical care.This study will allow biomedical research the ability to obtain specimens from patients with relevant diseases and appropriate clinical data. This study will collect patient demographic, clinical and historical data for a registry and patient samples will be deposited in the Poseidon biobank. Patients do not have to be diagnosed with Kidney Disease to be included in this study.

Institution
MUSC
Recruitment Contact
Linda Walker
8437926109
walkerlp@musc.edu

"Prognostic markers in postoperative acute kidney injury" Save

Date Added
October 5th, 2009
IRB Number
10497
Researcher
Joshua Lipschutz

List of Studies

Silhouette
Keywords
Cardiovascular, Heart, Kidney
Summary

Kidney failure occurring after heart failure is a serious problem leading to prolonged ICU stay, prolonged hospitalization, dialysis and death. The goal of this study is to identify patients who will develop severe kidney failure after heart surgery. Early identification of patients who will develop kidney failure after surgery will allow earlier and better treatment to prevent this complication. In this study, urine is collected after surgery and analyzed to determine the concentration of many proteins. These proteins are potential biomarkers to predict the development of kidney failure. This is a multi-center study funded by the National Institutes of Health. It is being performed at Duke University, George Washington University and the University of Tennessee. MUSC is the lead center.

Institution
MUSC
Recruitment Contact
Linda Walker
843-792-6109
walkerlp@musc.edu

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