Cigarette smoking is the leading preventable cause of death and disability in the U.S. and individuals with elevated depression symptoms or clinically diagnosed major depressive disorder (MDD) smoke at significantly higher rates than non-depressed individuals. Elevated negative affect and affective dysregulated emotional control may contribute to greater smoking among individuals with MDD. The proposed research will shed new light on the neural mechanisms that govern associations between depression and smoking. Despite known and costly associations between these factors, little is known regarding their co-occurrence and such information will provide a foundation for the development of novel and more effective interventions. We are recruiting adult smokers and nonsmokers, and individuals with or without depression, ages 18 and older to participate.
This research is being conducted to investigate the association of personal, environmental, and occupational risk factors and ALS. A web-based survey that includes questions about demographics, medical history, family history of neurological disorders, hobbies, military history, smoking, physical activity, residential history, and occupational history, etc. will be completed by ALS patients as well as controls without ALS to compare differences among the two groups.