Evaluating smoking and relapse in adolescents and emerging adults using remote monitoring technology Save

Date Added
November 1st, 2016
PRO Number
Pro00060290
Researcher
Erin Mcclure

List of Studies


Profiles_link
Keywords
Adolescents, Smoking
Summary

This is a research study that will test a new remote monitoring technology to assess smoking in the natural environment among adolescents and young adults ages 18-25. After assessment and inclusion in the study, participants will be asked to report on their smoking or vaping patterns by answering questions on a mobile phone for 35 days. Participants will also be asked to make a brief quit attempt lasting for approximately 48 hours. There is no cost to participate and compensation is available to those who qualify.

Institution
MUSC
Recruitment Contact
Intake Team
843-792-4097
mymobilemonitor@musc.edu

Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer (PIP) Save

Date Added
October 18th, 2016
PRO Number
Pro00057768
Researcher
Benjamin Toll

List of Studies


Profiles_link
Keywords
Lung, Smoking
Summary

Smoking cessation is the most important strategy available to reduce lung cancer risk. To date, there has been no research on tobacco cessation in lung screening patients, who may have unique attributes (e.g., anxiety about having a nodule coupled with tobacco dependence). We thus propose to evaluate 2 novel behavioral interventions as adjuncts to standard pharmacotherapy. We will enroll and randomize 276 patients undergoing lung screening to Intervention 1 (gain-framed personalized video and print intervention). We will evaluate whether this will improve tobacco quit rates above and beyond standard of care smoking cessation treatment over 8 weeks. Then we will perform a second randomization to Intervention 2, an individual-level, biofeedback intervention. We will then evaluate whether this intervention will reduce smoking rates at 6 months.

Institution
MUSC
Recruitment Contact
Nortorious Coleman
843-509-7589
colemann@musc.edu

Gain-framed Messages and NRT Sampling to Promote Smoking Cessation in Lung Cancer Screening Programs Save

Date Added
June 21st, 2016
PRO Number
Pro00055397
Researcher
Benjamin Toll

List of Studies


Profiles_link
Keywords
Lung, Pulmonary, Smoking
Summary

This research is a randomized smoking cessation trial conducted within and specifically personalized for lung cancer screening patients presenting to a lung screening clinic. Novel tobacco treatments for this population are critically needed, given the growing population of lung screening patients. In the proposed study, we will test a gain-framed messaging intervention specifically designed for lung screening patients (vs. unframed messaging), as well as evaluating NRT sampling (vs. no medication).

Institution
MUSC
Recruitment Contact
Nortorious Coleman
843-509-7589
colemann@musc.edu

The Watch the Spot Trial Save

Date Added
June 10th, 2016
PRO Number
Pro00044920
Researcher
Gerard Silvestri

List of Studies


Profiles_link
Keywords
Cancer, Lung, Pulmonary
Summary

The study will compare two sets of professionally-recommended guidelines for follow-up of patients with small lung nodules. The two guidelines are different in the frequency and timing of follow-up; one is more frequent and the one is less frequent. All patients who have a small lung nodule detected on a chest scan will have a recommended follow-up schedule automatically inserted into their imaging report so that their health care provider may follow the guideline-recommended intervals for follow-up chest scans. Patients and their physicians may choose not to follow the recommendations, depending on preference or the physician's clinical judgment. As part of this research study, information from patients with a small lung nodule who are seen at MUSC will be collected from the electronic medical record. This will include characteristics of the patient (such as age, smoking history), basic information about the lung nodule (such as nodule size, nodule density), and the medical care received.

Institution
MUSC
Recruitment Contact
Katherine Taylor
843-792-2297
taylkat@musc.edu

Evaluating N-acetylcysteine as a pharmacotherapy for tobacco use disorder Save

Date Added
March 1st, 2016
PRO Number
Pro00052793
Researcher
Erin Mcclure

List of Studies


Profiles_link
Keywords
Drug Studies, Smoking
Summary

The purpose of this study is to assess the effects of N-Acetylcysteine (NAC), an over-the-counter antioxidant, to assist adult cigarette smokers with quitting and preventing relapse to smoking. This medication may help people quit smoking by reducing withdrawal symptoms, craving, and preventing relapse, but we do not know if NAC helps smokers early in their quit attempt or after they have already quit.

Institution
MUSC
Recruitment Contact
Intake Team
843-792-4097
smokingstudy@musc.edu

Translational Neuropsychopharmacology Research of Nicotine Addiction Save

Date Added
October 20th, 2015
PRO Number
Pro00048152
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Smoking
Summary

This study is investigating the effects of combining 2 medications, Varenicline (commonly known as Chantix®) and N-acetylcysteine, on smoking behavior in daily cigarette smokers who are interested in quitting smoking. The study consists of 10 visits over 6 weeks. Compensation is available for those that qualify. Smokers must be between the ages of 18 and 55.

Institution
MUSC
Recruitment Contact
Shannon Powers
843-882-7196
powerssh@musc.edu

CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL Save

Date Added
July 6th, 2015
PRO Number
Pro00043906
Researcher
Christine Holmstedt

List of Studies


Profiles_link
Keywords
Stroke
Summary

CREST-2 is two parallel multi-center randomized, observer-blinded endpoint clinical trials. One trial will assess treatment differences between intensive medical management alone compared to carotid endarterectomy procedure plus intensive medical management. The parallel trial will assess treatment differences between intensive medical management alone compared to carotid artery stenting plus intensive medical management. Intensive medical management will involve control of blood pressure, LDL cholesterol, cigarette smoking, and other vascular risk factors.

Institution
MUSC
Recruitment Contact
Robert Burfeind
843-792-8606
burfeind@musc.edu

Synchronized-EEG Method for Automatically-delivered Real Time (SMART) Transcranial Magnetic Stimulation (TMS) for Nicotine Addiction Save

Date Added
October 7th, 2014
PRO Number
Pro00034876
Researcher
Xingbao Li

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies, Smoking
Summary

Nicotine dependence remains a significant public health concern. Nicotine can affect brain neural oscillations. A magnetic field applied to the outside of the skull can produce electrical activity in the brain without significant pain or the need for anesthesia. In this proposal, we will build an individual brain signal-driven transcranial magnetic stimulation loop, and then test whether this stimulation loop can modulate neural oscillations and reduce cue-induced craving, including nicotine craving. This research will build an innovative brain stimulation method for neuroscientific research and develop a potential efficacy therapy for nicotine dependence as well other neuropsychiatric disorders.

Institution
MUSC
Recruitment Contact
John Henderson
843 792 5560
henderjs@musc.edu

A Prospective, Double Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of the Deep Transcranial Magnetic Stimulation (DTMS) (with the H-ADD Coil) intended as an aid to Smoking Cessation Save

Date Added
April 8th, 2014
PRO Number
Pro00033326
Researcher
Mark George

List of Studies


Profiles_link
Keywords
Pulmonary, Smoking
Summary

This research is being conducted at the Medical University of South Carolina Institute of Psychiatry Brain Stimulation Lab by Dr. Mark George to see if deep repetitive transcranial magnetic stimulation (dTMS) is effective in assisting participants to quit smoking. TMS is a noninvasive medical procedure that uses magnetic fields to stimulate nerve cells in the brain to act as an aid to smoking cessation. The treatment period will involve 18 active/sham treatments to be given daily for 3 weeks then weekly treatments in week 4, 5, and 6. A follow up visit will be scheduled about 2 1/2 months after week 6. The entire study is four months in duration. Participants who may be recruited into the study would include the following: men and women 22-70 years of age, chronic; heavy smokers who have smoked for more than 1 year, with no period of abstinence greater than 3 months during the past year; subjects who are motivated to quit smoking; subjects who have negative answers on the TASS; and those who are able to sign an informed consent.

Institution
MUSC
Recruitment Contact
Jkeonye Moss
843-876-5141
mosjk@musc.edu

Repetitive TMS Modulates Dorsal Lateral Prefrontal-Ventral Medial Prefrontal Pathway to Decrease Craving in Smokers Save

Date Added
March 4th, 2014
PRO Number
Pro00032649
Researcher
Xingbao Li

List of Studies


Profiles_link
Keywords
Brain, Smoking
Summary

Cigarette smoking causes significant morbidity and mortality in the United States. Smoking cessation is difficult, with the average smoker attempting to quit five times before permanent success. Moreover, the majority of smoking quit attempts result in relapse. Brain stimulation for smoke cessation is an exciting new area that builds on advancing neuroscience knowledge concerning the functional neurocircuitry of addiction. Cortical stimulation can now be performed non-invasively by transcranial magnetic stimulation (TMS). Several studies have shown that TMS can reduce cue-elicited craving in smokers. Previous research by our group has shown that a single session of 15 minutes high frequency (10 Hz) repetitive TMS (rTMS) at 100% motor threshold over the left dorsal lateral prefrontal cortex (DLPFC) can reduce cue-induced craving compared to sham TMS. However, the mechanism by which craving is reduced by rTMS is poorly understood both at behavioral and neural levels. Neuroimaging studies in nicotine dependence have revealed cue-related responses in numerous brain areas, including frontal, parietal cortices and subcortical areas. Recently functional magnetic resonance imaging (fMRI) studies by our group have shown that cue-induced craving induced brain activation in ventral medial prefrontal cortex (VMPFC), including medial frontal, orbital frontal and anterior cingulate. This Chair Research Development Fund (CRDF) pilot proposal will integrate two new techniques- TMS and fMRI to investigate DLPFC-VMPFC pathway in smokers. Using double-masked methods we hypothesize that cue-induced exposure will induce brain activity in VMPFC, and 15 minutes rTMS over DLPFC will reduce cue-induced craving through modulating DLPFC-VMPFC pathway (increased activity DLPFC and decreased activity VMPFC). In the one year of project, we plan to recruit 10 non-treatment-seeking nicotine-dependent cigarette smokers and 20 non-smoking participants, both males and females of all ethnic and racial groups between the ages of 18 and 60 to participate in the study. The participants will randomly receive two different types of brain stimulation: active rTMS or sham rTMS over the left DLPFC with a 1 week interval between treatments. MRI scans will be completed pre and post rTMS. The data from this pilot will provide the information needed for submitting a larger-scale investigation (R01) to investigate cue craving neutral pathway and develop a potential clinical applications of TMS in smoke cessation.

Institution
MUSC
Recruitment Contact
William DeVries
843 7925729
devriesw@musc.edu

Change_preferences

-- OR --

Create_login