PEPPER is a randomized study comparing the three most commonly used blood thinners in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The blood thinners being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.

This study aims to identify which supplemental intervention components could be added to an online physical activity program that contribute to the greatest increases in physical activity in adults with knee replacement. The 4 supplemental intervention components include phone coaching, progress reports to physicians, tailored modules, and personalized feedback. Using the most effective components, an optimized Energize! Exercise intervention will be developed for testing in a subsequent trial.

This study will examine the effects of 3 different physical activity goals on arthritis-related outcomes in adults with arthritis. Participants will be randomized to either 45 minutes/week, 90 minutes/week, or 150 minutes/week. Additionally, this study will examine how daily activity can influence arthritis-related outcomes such as pain and fatigue.