The purpose of this clinical study is to see whether injections of AbobotulinumtoxinA in the upper limb (arm) and lower limb (leg) in combination with a personal exercise plan can improve voluntary movements in subjects with hemiparesis.
In this study, we plan to record electric fields (EF) in the brain while transcranial direct current stimulation (tDCS) is applied through the scalp. We will include patients who are scheduled to undergo deep brain stimulation (DBS) procedure to participate in the study, after explaining the procedures, answering any questions and receiving informed consent. The study might prolong the duration of the DBS procedure by a few minutes because of the time taken to apply tDCS. However, no other deviations from standard DBS procedures will be made. That is, no additional DBS electrode penetrations will be performed for research purposes - we will record from DBS electrodes that are being inserted exclusively as a part of clinical care.
During the acute stroke phase, physicians are frequently asked by patients and or their family members about their recovery potential and functional outcome at 3 months. It is of critical importance for clinicians to predict motor outcome from the acute phase. Being able to make outcome predictions in the acute phase allows clinicians to triage patients for the most appropriate rehabilitation and provides the patient and the patient's caregivers with a reasonable expectation of functional recovery. This study aim to predict motor outcomes at 3 months post-stroke using mutliple measures including neuroimaging, genetic and behavioral measures collected during the acute phase.