This study is for patients that have been diagnosed with diffuse large B-cell lymphoma (DLBCL) or Grade 3b follicular lymphoma that has never been treated. The investigational drug in this study is denintuzumab mafodotin. The purpose of this study is to find out what the side effects are and whether it is more or less effective when it is given together with other drugs that are a standard approved treatment for use in patients with lymphoma (DLBCL or FL3B). Participants can expect to be in the study for 4 years or until the study is closed or until they stop taking part.
This study is for patients that have been diagnosed with 1 of the following types of cancer : Chronic Lymphocytic Leukemia (CLL), Small-Cell Lymphocytic Lymphoma (SLL), or of Non-Hodgkin Lymphoma (NHL) of which there are 2 mains types: B-Cell NHL or T-Cell NHL. The investigational drug being studied is PRT062070; it is also called ?cerdulatinib.?The primary purpose of Phase 2a of this study is to assess safety and the activity of the study drug in patients who have CLL, SLL, or B-cell NHL, or T-cell NHL. You will take the study drug until you withdraw your agreement to continue to take part in this study, your cancer becomes worse, you have severe side effects, the research study ends, or you have completed dosing with the study drug and all follow-up study visits.
This study is for patients that have been diagnosed with Non-Hodgkin Lymphoma (NHL) and Diffuse Large B-Cell Lymphoma (DLBCL). The investigational drug in this study is Entospletinib (GS-9973) [referred to as ENTO]. The purpose of this study is to see if the study drug, ENTO can benefit subjects with Non-Hodgkin Lymphoma,can safely be combined with vincristine (VCR) and can have a beneficial effect in combination with VCR and VCR-based combination therapy (R-CHOP and DA-R-EPOCH). Participants can expect to be in this study for up to 5 years.
This study is for patients that have been diagnosed with certain advanced cancers or diseases where cells grow too much including leukemia (for example, Acute Myeloid Leukemia [AML]), Myelodysplastic Syndrome (MDS), Myelodysplastic/ Myeloproliferative Neoplasms (MDS/MPN), Myelofibrosis (MF), Multiple Myeloma (MM), and lymphoproliferative disporders (LPDs). The investigational drug in this study is INCB053914. The purpose of this study is to evaluate the safety and tolerability and to select the doses that will be studied further. Participants can expect to be in this study for about 4 to 6 months but this will vary depending on if conditions occur, such as progression of disease, new findings during the study or the study finishes.