MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study Save

Date Added
September 10th, 2019
PRO Number
Pro00088665
Researcher
Souvik Sen

List of Studies

Keywords
Stroke, Stroke Recovery
Summary

MultiStem is regenerative medicine derived from donated human cells to treat acute ischemic stroke within 36 hours after symptom onset. Stroke leads to brain cell injury and many stroke patients suffer functional deficits as results. The purpose of this study is to evaluate safety and effectiveness of MultiStem on functional outcome in subjects with ischemic stroke.

Institution
Palmetto
Recruitment Contact
Mihyun Lim
803-545-6078
Mihyun.Lim@uscmed.sc.edu

Sleep for Stroke Management And Recovery Trial Save

Date Added
May 22nd, 2019
PRO Number
Pro00084906
Researcher
Souvik Sen

List of Studies

Keywords
Sleep Disorders, Stroke
Summary

Investigator-initiated, phase 3 multicenter, prospective randomized open-, blinded-endpoint (PROBE) controlled trial to test whether treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure is effective for secondary prevention and recovery after stroke.

Patients with recent (?14 days) acute ischemic stroke or high-risk TIA (ABCD2 ?4) are enrolled during their acute or rehabilitation hospitalization and treated for 6 months. After consent, a portable cardiopulmonary sleep apnea test (the Nox T3) is used to screen for OSA (AHIT3?10) and to exclude central sleep apnea (where CAI ?50% of the total AHIT3). aCPAP is then used on one night to determine tolerability (the "run-in" night). Subjects who use the device for ?4 hours on that night, and do not have excessive treatment-emergent central sleep apnea (CAI remains <10 on aCPAP machine-generated data), are randomized to receive either 6 months of aCPAP plus usual medical therapy, or usual medical therapy alone. Adherence information is provided to subjects in the intervention group, to offer education about treatment and to increase treatment adherence. Subjects and their caregivers also are taught about aCPAP use. Through a centralized service, managed by FusionHealth, adherence to aCPAP is monitored in nearly real time in most cases by wireless means, and supported remotely throughout the treatment period.

Institution
Palmetto
Recruitment Contact
Mihyun Lim
803-545-6078
mihyun.lim@uscmed.sc.edu

A Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled, Response-Adaptive Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA) Save

Date Added
April 5th, 2019
PRO Number
Pro00083102
Researcher
Souvik Sen

List of Studies

Keywords
Stroke, Stroke Recovery
Summary

Factor XI is a protein involved in the blood clotting cascade. Blood clots frequently block brain blood vessels causing ischemic strokes. Bleeding in the brain is a major concern for clinicians when treating patients with stroke or risk for stroke. Over the last decade, a new type of drug called a selective oral direct thrombin and Factor Xa inhibitors (DOACs) has been introduced that reduces the likelihood of bleeding when treating and preventing strokes. The purpose of this study is to test the safety and effectiveness of a new stroke medication that block Factor XI and compare it to aspirin alone, especially regarding prevention of stroke without increasing the risk of brain bleeding.

Institution
Palmetto
Recruitment Contact
Mihyun Lim
8035456078
mihyun.lim@uscmed.sc.edu

DESIRE: DisparitiES In intRacerebral hEmorrhage study Save

Date Added
May 31st, 2018
PRO Number
Pro00077752
Researcher
Souvik Sen

List of Studies

Keywords
Stroke
Summary

This study is gathering patient information and a saliva sample from people who have had a type of stroke called an intracerebral hemorrhage (ICH). Risk factors will be identified and analyzed for their contribution to the ICH as well as their effect on long term patient outcomes. Patients will be contacted over phone at 3 and 12 months after enrollment and asked a series of short questions about how they are feeling, how hard or easy it is to perform daily tasks, and any change in medication.

Institution
Palmetto
Recruitment Contact
Brittiny McMillian
803-545-6103
brittiny.mcmillian@uscmed.sc.edu

PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke Save

Date Added
July 21st, 2015
PRO Number
Pro00044329
Researcher
Souvik Sen

List of Studies

Keywords
Periodontal Disease, Stroke, Vascular
Summary

The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic stroke and TIA survivors. The study uses the resources in both states including established
dental centers, Joint Commission Certified Stroke Centers, the Schools of Public Health, and the Institute for Partnerships to Eliminate Health Disparities. The proposal addresses specific issues with regards to recruitment of African-American and rural stroke/TIA patients advocating the use of culturally appropriate strategies to educate the study subjects regarding stroke, periodontal disease and the periodontal stroke link.
The study proposes to utilize economic evaluation of the periodontal intervention from the budgetary
perspective. The focus will be on the financial sustainability of providing aggressive periodontal therapy (with
certain, although relatively low expenditures) in exchange for a reduction of uncertain recurrent vascular events
that may require high cost emergency department utilization and/or inpatient care. The sustainability of the
proposed intervention after the completion of the project is integrally linked to the health economic assessment
to show the health care cost savings. By integration with a rural primary care center, with an African American
majority and households with average incomes below the state average, the study ensures that the proposed
intervention to reduce stroke disparity is applicable to this target population.

Institution
Palmetto
Recruitment Contact
Lauren Giamberardino
8035456078
lauren.dennis@uscmed.sc.du

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