Heart Failure in Single Right Ventricle Physiology: Pathologic Mechanisms and Novel Assessment Save

Date Added
July 5th, 2017
PRO Number
Pro00066472
Researcher
Shahryar Chowdhury

Silhouette
Keywords
Cardiovascular, Children's Health, Heart, Pediatrics
Summary

The goals of this study are to understand the mechanisms behind the development of heart failure in children born with complicated heart defects consisting of a functional single pumping chamber, improve the ability to objectively measure cardiac function in these patients and determine the relationship of these pathophysiologic mechanisms to outcomes.

Institution
MUSC
Recruitment Contact
Christine Perez-Rosa
843-792-9454
perezaro@musc.edu

Gold-standard Measures of Diastolic Function in Single Ventricle Physiology Prior to Stage 3 Palliation: Correlations with Echocardiography and Relationship to Outcomes Save

Date Added
July 1st, 2014
PRO Number
Pro00034502
Researcher
Shahryar Chowdhury

Silhouette
Keywords
Cardiovascular, Children's Health, Heart, Pediatrics
Summary

In recent decades, the intense interest in the contribution of diastolic dysfunction to adult heart failure has resulted in a number of echocardiographic methods to evaluate diastolic function. To evaluate their accuracy, echocardiographic measurements of diastolic function have been validated with gold-standard measures derived from micromanometer pressure analysis in the adult heart failure population. However, no studies have assessed the accuracy of echocardiographic measures of diastolic function in the single ventricle population. Also, the relationship between echocardiographic measures of diastolic function and outcomes in the single ventricle population ? an exercise necessary to determine their clinical usefulness - has not been investigated. The specific aims of this study seek to validate the accuracy and clinical utility of these non-invasive indices in the single ventricle population

Institution
MUSC
Recruitment Contact
Patricia Infinger
803-792-7857
infingep@musc.edu

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