Effect of GET73 on magnetic resonance spectroscopy measures of central glutamate and GABA and alcohol cue-elicited brain activation in recently abstinent non-treatment-seeking individuals with Alcohol Use Disorder Save

Date Added
September 26th, 2017
PRO Number
Pro00069862
Researcher
Raymond Anton

List of Studies


Profiles_link
Keywords
Alcohol, Brain, Drug Studies, Substance Use
Summary

The purpose of this study is to evaluate the potential mechanism of action and the safety of GET73, a new drug under development for the reduction of craving and drinking in alcohol dependent individuals. The study involves five to six visits over a three to four week period, including one to two assessment visits and two visits during which participants will be assigned to take, in a double-blinded fashion, both GET73 and a placebo (two visits during each condition). During three of these visits, participants will undergo a one-hour MRI scan. Compensation is available for qualified participants.

Institution
MUSC
Recruitment Contact
Katy Fuqua
(843) 792-1452
fuquama@musc.edu

Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control Save

Date Added
December 1st, 2015
PRO Number
Pro00050157
Researcher
Raymond Anton

List of Studies


Profiles_link
Keywords
Alcohol, Brain, Substance Use
Summary

This study examines the effects of the medication tolcapone among individuals who regularly drink alcohol. Participants in this study will be randomly assigned to take either tolcapone or a matched placebo for 8 days. There are 3 study visits, including 2 MRI scans, and a debriefing session. This study does not involve alcohol treatment. Interested individuals must be referred for participation by the Charleston Alcohol Research Center Clinical Intake and Assessment Core. For more information, call 792-1222 or email alcoholstudy@musc.edu.

Institution
MUSC
Recruitment Contact
Charleston Alcohol Research Center
(843) 792-1222
alcoholstudy@musc.edu

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