Effect of GET73 on magnetic resonance spectroscopy measures of central glutamate and GABA and alcohol cue-elicited brain activation in recently abstinent non-treatment-seeking individuals with Alcohol Use Disorder Save

Date Added
September 26th, 2017
PRO Number
Pro00069862
Researcher
Raymond Anton

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Keywords
Alcohol, Brain, Drug Studies, Substance Use
Summary

The purpose of this study is to evaluate the potential mechanism of action and the safety of GET73, a new drug under development for the reduction of craving and drinking in alcohol dependent individuals. The study involves five to six visits over a three to four week period, including one to two assessment visits and two visits during which participants will be assigned to take, in a double-blinded fashion, both GET73 and a placebo (two visits during each condition). During three of these visits, participants will undergo a one-hour MRI scan. Compensation is available for qualified participants.

Institution
MUSC
Recruitment Contact
Kelsey Gnade
(843) 792-7588
gnade@musc.edu

Gabapentin for Relapse Prevention: Alcohol Withdrawal-Brain GABA/Glutamate Effects Save

Date Added
March 4th, 2014
PRO Number
Pro00032587
Researcher
Raymond Anton

Silhouette
Keywords
Alcohol, Brain, Drug Studies, Stage III, Substance Use
Summary

This treatment study is an16-weeks outpatient clinical trial where subjects will get medication, which might help them to reduce or stop their drinking or a placebo ( placebo is a capsule that looks the same as the investigational drug, but has no real medication. It is a "sugar pill"). This study will recruit and randomize subjects who have expressed an interest in receiving treatment for alcohol dependence. Upon enrollment into this study there will be 11 outpatient visits. Each visit will last about 1-1.5 hours.

Institution
MUSC
Recruitment Contact
Konstantin Voronin
843-792-4887
voronin@musc.edu

IMPULSIVITY AND DRINKING/CRAVING: EFFECT OF A DOPAMINE STABILIZER MEDICATION Save

Date Added
March 29th, 2011
IRB Number
20459
Researcher
Raymond Anton

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Keywords
Alcohol
Summary

MUSC Center For Drug And Alcohol Programs is conducting an alcohol research study investigating the effects of a medication in response to alcohol. Individuals (ages 21-40) who complete the study will be paid for their participation. This study does not involve alcohol treatment. For more information, call Mark at 792-1222.

Institution
MUSC
Recruitment Contact
Mark Ghent
843-792-1222
ghent@musc.edu

Genetic and brain mechanisms of naltrexone?s treatment efficacy for alcoholism Save

Date Added
October 5th, 2009
IRB Number
18846
Researcher
Raymond Anton

Silhouette
Keywords
Alcohol
Summary

Looking for men and women ages 18 to 70 who are alcohol dependent and currently drink and are otherwise generally healthy. The treatment period is 16 weeks with medication called naltrexone or placebo taken daily. There will be 9 visits during the treatment period and two follow up visits on weeks 28 and 40. Participants will be seen by a medical provider (MD or nurse), blood tests will be done prior to and during participation.

Institution
MUSC
Recruitment Contact
Dr.Konstantin Voronin or Dr.Pat Latham
843-792-2727
voronin@musc.edu

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