Efavirenz Plasma Concentrations in Obese, Human Immunodeficiency Virus (HIV)-Infected Subjects Save

Date Added
November 24th, 2015
PRO Number
Pro00048345
Researcher
Rachel Foster
Keywords
HIV / AIDS, Obesity
Summary

This prospective, single-site, pharmacokinetic, cohort study will examine the effects of obesity on plasma drug concentrations of efavirenz. Concentrations from two different times (random and 12-hour sample) will help form subject-specific pharmacokinetic drug curves to evaluate obesity's effects on efavirenz concentrations. Forty subjects (10 normal weight, 10 overweight, 10 obese, and 10 extremely obese) will be enrolled.

Institution
Palmetto
Recruitment Contact
Rachel Foster
(803) 434-2925
fosterr8@sccp.sc.edu

Temporal impact of broad-spectrum, empirical antibiotic therapy on host microbiome in hospitalized patients Save

Date Added
October 19th, 2015
PRO Number
Pro00048239
Researcher
Rachel Foster
Keywords
Infectious Diseases, Non-interventional
Summary

This pilot study is designed as a preliminary study to determine if a significant difference exists in the stool bacterial diversity of hospitalized patients on broad-spectrum antibiotics during different points in their course of therapy. Fecal samples will be collected from study subjects at pre-defined time intervals (baseline, >48 to 96 to 144 to <192 hours) during their course of antibiotic therapy. Stool samples will be analyzed for the number and abundance (diversity) of bacterial species present.

Institution
Palmetto
Recruitment Contact
Rachel Foster
(803) 434-2925
fosterr8@sccp.sc.edu

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