Evaluate the long-term safety and maintenance of efficacy of AVP-786 for the treatment of agitation in patients with dementia of the Alzheimer's type in Veterans at the Ralph H. Johnson VA Medical Center in Charleston, SC.
Inclusion in this study requires successful completion of studies 15-AVP-786-301, 15-AVP-786-302, 17-AVP-786-305 or 12-AVR-131 and a reliable caregiver who is able and willing to comply with all required study procedures.
The objectives of the study are to evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type.
Major depressive disorder (MDD) is a mental illness in which affected individuals have low mood with low self-esteem, and loss of interest or pleasure in normally enjoyable activities. It is a long-term illness for many subjects and maintenance therapy is recommended to prevent relapse in subjects with recurrent depression.
The purpose of this study is to test the efficacy and safety of doses of vortioxetine capsules (5, 10 or 20 mg/day) compared with placebo (a non-active capsule/ "dummy drug") in preventing relapse in people with acute recurrent MDD.