Impact of lofexidine on stress, craving and opioid use Save

Date Added
September 4th, 2018
PRO Number
Pro00081381
Researcher
Kathleen Brady
Keywords
Drug Studies, Psychiatry
Summary

The purpose of this study is to determine if the medication lofexidine, taken together with buprenorphine, is more effective at reducing opiate craving, use and stress response than buprenorphine alone, and to see if this effect is different for men and women. Participants are randomly assigned to add either lofexidine or placebo to their buprenorphine treatment for five weeks. They return at the end of five weeks to participate in a stress task. Throughout the study, participants complete "CREMA" sessions (Cue Reactivity Ecologic Momentary Assessment) twice a day. These sessions include looking at stressful and neutral pictures and rating stress and craving.

Institution
MUSC
Recruitment Contact
Amanda Wagner
843-792-0484
wagne@musc.edu

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