Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD Save

Date Added
December 19th, 2017
PRO Number
Pro00073604
Researcher
Joseph Helpern

Silhouette
Keywords
Aging, Alzheimers, Brain, Healthy Volunteer Studies
Summary

The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.

Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.

Institution
MUSC
Recruitment Contact
Mallory Gillen
843-876-7034
gillenm@musc.edu

Brain Biomarkers of ADHD with High Risk for Substance Use Disorders Save

Date Added
May 5th, 2015
PRO Number
Pro00043719
Researcher
Joseph Helpern

Silhouette
Keywords
ADD/ADHD, Adolescents, Brain, Substance Use
Summary

Adolescents with attention-deficit/hyperactivity disorder (ADHD) are nearly three times more likely to develop substance use disorders (SUD) than their typically developing peers, yet there currently are no biomarkers that can help clinicians identify which ADHD patients are at higher SUD risk and thus, who may benefit most from SUD prevention. This is a critical problem, given that ADHD psychostimulant medications ? which are Schedule II Controlled Substances ? are misused and abused by 26.7% of this population. In this research study, non-invasive MRI methods will be used to examine brain structural connectivity (i.e., number of neural fiber connections) and brain iron (as an index of dopamine) as possible brain biomarkers of increased SUD risk in ADHD.

Institution
MUSC
Recruitment Contact
Vitria Adisetiyo
843-640-5382
ADHDbrainMUSC@gmail.com

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