This randomized phase II trial studies how well erlotinib hydrochloride or crizotinib with chemoradiation therapy works in treating patients with stage III non-small cell lung cancer. Radiation therapy uses high energy x rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin, etoposide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving erlotinib hydrochloride is more effective than crizotinib with chemoradiation therapy in treating patients with non-small cell lung cancer.
Patients will be randomized to 1 of 4 treatment arms. After completion of study treatment, patients are followed up at 1 and 2 months, 4-6 weeks, every 3 months for 2 years, every 6 months for 3 years, and then annually for 5 years.
Many women being treated for breast cancer are treated with drugs known as aromatase inhibitors, which stop the production of estrogen in post-menopausal women. Women taking these drugs often report muscle and joint aches. This is referred to as Aromatase Inhibitor Musculoskeletal Symptoms, or "AIMSS." The reasons for these muscle and joint pains are not known. This study is being conducted to determine the good and/or bad effects of an aromatase inhibitor known as anastrazole on post-menopausal women being treated for breast cancer, and whether their genes can help explain how anastrazole affects the body. The study also hopes to look at how the side efffects from hormone therapy influence patients' quality of life and willingness to continue hormonal treatment.