Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar Alcoholics Save

Date Added
April 4th, 2017
PRO Number
Pro00064964
Researcher
James Prisciandaro
Keywords
Alcohol, Depression, Mental Health, Psychiatry, Substance Use
Summary

This study examines the effects of the medication gabapentin and the supplement n-acetylcysteine among individuals with Bipolar Disorder who regularly drink alcohol. Participants in this study will take gabapentin, n-acetylcysteine, and matched placebo (one at a time) for 5 days each. There are 8 study visits, including 3 MRI scans.

Institution
MUSC
Recruitment Contact
Brecken Cornely
843-792-0572
cornely@musc.edu

Neuroimaging Mechanisms of Overlap Between Alcoholism and Bipolar Disorder Save

Date Added
October 2nd, 2012
PRO Number
Pro00019393
Researcher
James Prisciandaro
Keywords
Alcohol, Mental Health, Psychiatry, Substance Use
Summary

Bipolar disorders (BD) and substance use disorders (SUD) co-occur very frequently, and co-occurring BD and SUD are associated with devastating public health costs. Unfortunately, there has been very little neurobiological research involving individuals with co-occurring BD and SUD to guide the development of effective treatments for this treatment-resistant population. In response to this clinical need, the proposed study will evaluate a potential mechanistic model of BD and alcohol dependence (AD) co-occurrence, involving shared neurochemical and neurobehavioral dysregulations, that could help to identify novel therapeutic targets for individuals with co-occurring BD and AD. Additionally, the MRS follow-up sub-study will evaluate the effects of recent alcohol drinking (<=48hrs vs >=1 week) on brain neurochemistry in individuals with co-occurring BD and AD.

Institution
MUSC
Recruitment Contact
Helena Brenner
843-792-0572
brennerh@musc.edu

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