The purpose of this study is to evaluate the safety and tolerability of an experimental investigational drug called ixazomib (MLN9708) in patients with Lupus Nephritis. This study will compare ixazomib with a placebo to see if taking ixazomib is better than taking a placebo. The study will help to determine how ixazomib behaves inside the body/blood and how it is eliminated from the body. Also, this study will provide information on the effect that ixazomib may have on important characteristics of the lupus nephritis.
EMBRACE is a study of belimumab, also known as BENLYSTA, to treat lupus in adult black women and men. This study is being conducted to see if belimumab works and is safe for black patients. Patients will receive either belimumab or placebo (no drug) once a month in clinic for a year, plus their regular lupus medicines. For more information, contact Abby Powell at 843-792-0549.