The purpose of this research study is to measure how well and how safe BMS-986165 is in treating patients with Systemic Lupus Erythematosus (SLE) and to determine the optimal dose level.
Lupus is an autoimmune disease, which means that your immune system not only attacks bacteria and viruses but also attacks your healthy cells and organs, affecting many parts of the body. Lupus can cause fever, joint pain, rash (redness of the skin), sensitivity of the skin to sunlight, as well as other symptoms, and may lead to inflammation and organ damage.
Current treatments for Lupus are mainly drugs that suppress the immune system such as cortisone-like drugs (such as prednisone) and cyclophosphamide (a potent drug sometimes used in treating certain types of cancer), and drugs commonly used to treat or prevent malaria (called antimalarials) such as hydroxychloroquine. Many of these treatments may have serious side effects if used for a long time.
Therefore, there is a need for new and effective treatments for Lupus.
A severe manifestation of lupus is nephritis--when lupus is causing inflammation in the kidney. The current evaluation of lupus nephritis involves a biopsy of the kidney to assess the type of inflammation. We are investigating whether MRI could be used to look for the inflammation. We do not know the answer to the question currently. If your doctor thinks you need a kidney biopsy to assess your lupus the MRI would be added and then compared to what is seen on the biopsy.