A Multicentre, Randomised, Double-blind, Placebo-controlled, Phase 3 Study Evaluating the Efficacy and Safety of two doses of Anifrolumab in Adult Subjects with Active Systemic Lupus Erythematosus Save

Date Added
November 8th, 2016
PRO Number
Pro00060429
Researcher
Eric Zollars
Keywords
Autoimmune disease, Lupus
Summary

The purpose of this study is to determine whether the addition of Anifrolumab (MEDI 546) to a patient's current Lupus treatment is effective in reducing Lupus disease activity.

Lupus is an autoimmune disease, which means that your immune system not only attacks bacteria and viruses but also attacks your healthy cells and organs, affecting many parts of the body. Lupus can cause fever, joint pain, rash (redness of the skin), sensitivity of the skin to sunlight, as well as other symptoms, and may lead to inflammation and organ damage.

Current treatments for Lupus are mainly drugs that suppress the immune system such as cortisone-like drugs (such as prednisone) and cyclophosphamide (a potent drug sometimes used in treating certain types of cancer), and drugs commonly used to treat or prevent malaria (called antimalarials) such as hydroxychloroquine. Many of these treatments may have serious side effects if used for a long time. Therefore, there is a need for new and effective treatments for Lupus.

Institution
MUSC
Recruitment Contact
Angela Robinson
843-792-6043
robia@musc.edu

Dynamic Imaging of Variation in Lupus Nephritis ("DIVINE") Save

Date Added
August 15th, 2015
PRO Number
Pro00067531
Researcher
Eric Zollars
Keywords
Lupus
Summary

A severe manifestation of lupus is nephritis--when lupus is causing inflammation in the kidney. The current evaluation of lupus nephritis involves a biopsy of the kidney to assess the type of inflammation. We are investigating whether MRI could be used to look for the inflammation. We do not know the answer to the question currently. If your doctor thinks you need a kidney biopsy to assess your lupus the MRI would be added and then compared to what is seen on the biopsy.

Institution
MUSC
Recruitment Contact
Margaret Lindemuth
8437928613
hardinm@musc.edu

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