A Randomized Controlled Trial of N-Acetylcysteine for Alcohol Use Disorder and Comorbid PTSD Save

Date Added
August 2nd, 2016
PRO Number
Pro00056889
Researcher
Elizabeth Santa ana
Keywords
Alcohol, Anxiety, Stress Disorders, Substance Use
Summary

We are currently recruiting women and men ages 18-70 who have had trauma experience and who use alcohol. This research study includes 12 weekly therapy sessions as well as random assignment to receive either the study medication or placebo.
The study will examine the ability of N-acetylcysteine (NAC), an antioxidant/dietary supplement, to reduce the severity of alcohol cravings and withdrawal as well as symptoms associated with PTSD.

Institution
MUSC
Recruitment Contact
Stacey Sellers
843-792-5807
sellersst@musc.edu

Group Motivational Interviewing (GMI) for Homeless Veterans in VA Services Save

Date Added
July 1st, 2014
PRO Number
Pro00032504
Researcher
Elizabeth Santa ana
Keywords
Mental Health, Psychiatry
Summary

This is a randomized controlled trial comparing GMI to a control treatment condition (CT) across five critical outcomes. 186 Veterans in VA housing services (93 per treatment arm) will be enrolled with a diagnosis of alcohol or drug abuse/dependence. Recruitment will take place in Charleston VAMC HUD-VASH & GPD. Participants will be randomly assigned to (1) GMI or (2) CT, each consisting of 4 sessions, will attend a booster session at 2 months, and will be evaluated at 1, 3, and 6 months. Participants with a non-substance related DSM-IV-TR major Axis I disorder (e.g., MDD, PTSD) will be eligible for the study. Analyses will be conducted using generalized linear mixed models (GLMM) approach.

Institution
MUSC
Recruitment Contact
Kayla Lamb
(843) 789-7168
lamb@musc.edu

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