This a study of the efficacy, safety, and pharmacokinetics of SAGE-547 Injection in adult female subjects diagnosed with severe and moderate postpartum depression(PPD). The study will consist of an up to 7-day Screening Period, 3-day Treatment Period, and 30-day Follow-up Period. Subjects must remain as inpatient during the study Treatment Period, which is approximately 60 hours in duration. Assessments and laboratory samples will be collected during the Treatment Period and the Follow-up Period.
This study is looking at how increased number of stressful life events and perceived racial discrimination might affect outcomes in pregnancy for pregnant women. We are recruiting pregnant women to be in the study, which will involve answering questions about stressful events occurring in childhood and adulthood, and will measure responses to stressful events and monitor outcomes of the pregnancy.