Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction Save

Date Added
April 16th, 2019
PRO Number
Pro00086509
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Smoking
Summary

Nicotine addiction is a chronic, relapsing brain disorder and although it is the leading cause of preventable premature death in the US, ~20% of adults smoke and among those that try to quit, the majority relapse.Research suggest that nicotine addiction disrupts the working in the brain involved in motivation and reward. The overarching goal of this proposal is to utilize clinical neuroscience to investigate the effects of Mindfulness Oriented Recovery Enhancement (MORE) on modifying behavior to help treat nicotine addiction.

Institution
MUSC
Recruitment Contact
Katherine Lastrapes
8437927865
lastrape@musc.edu

An fMRI pilot study of the effects of Clavulanic Acid on cigarette withdrawal Save

Date Added
September 18th, 2018
PRO Number
Pro00078213
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Smoking
Summary

The broad objective of this proposal is to use fMRI methods to conduct preliminary investigation of the effects of Clavulanic Acid on neurocognition and smoking withdrawal in abstinent cigarette smokers. This project will involve collecting data from a total of approximately 40 adult smokers.

Institution
MUSC
Recruitment Contact
Shannon Powers
843-882-7196
powerssh@musc.edu

Examining the effects of Theta Burst Stimulation on corticothalamic mediated inhibitory control and smoking relapse vulnerability Save

Date Added
February 20th, 2018
PRO Number
Pro00074836
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Brain, Smoking
Summary

MUSC is recruiting adult cigarette smokers (18 to 65) who are interested in participating in a research study examining the effects of brain stimulation on neural activity and behavior. This study consists of 4 visits over the course of 2-3 weeks. Qualified individuals will be compensated for participation.

Institution
MUSC
Recruitment Contact
Makayla Joy Gibson
(803) 814-4017
mjgibson@email.sc.edu

Translational Neuropsychopharmacology Research of Nicotine Addiction Save

Date Added
October 20th, 2015
PRO Number
Pro00048152
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Smoking
Summary

This study is investigating the effects of combining 2 medications, Varenicline (commonly known as Chantix®) and N-acetylcysteine, on smoking behavior in daily cigarette smokers who are interested in quitting smoking. The study consists of 10 visits over 6 weeks. Compensation is available for those that qualify. Smokers must be between the ages of 18 and 55.

Institution
MUSC
Recruitment Contact
Shannon Powers
843-882-7196
powerssh@musc.edu

Neuroimaging of Nicotine Dependence, Depression and Emotion Regulation Save

Date Added
February 19th, 2013
PRO Number
Pro00022668
Researcher
Brett Froeliger

List of Studies


Profiles_link
Keywords
Depression, Smoking
Summary

Cigarette smoking is the leading preventable cause of death and disability in the U.S. and individuals with elevated depression symptoms or clinically diagnosed major depressive disorder (MDD) smoke at significantly higher rates than non-depressed individuals. Elevated negative affect and affective dysregulated emotional control may contribute to greater smoking among individuals with MDD. The proposed research will shed new light on the neural mechanisms that govern associations between depression and smoking. Despite known and costly associations between these factors, little is known regarding their co-occurrence and such information will provide a foundation for the development of novel and more effective interventions. We are recruiting adult smokers and nonsmokers, and individuals with or without depression, ages 18 and older to participate.

Institution
MUSC
Recruitment Contact
Shannon Powers
843-882-7196
powerssh@musc.edu

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