At-Home Transcutaneous Auricular Neuromodulation for Hypermobile Ehlers Danlos Syndrome

Date Added
July 5th, 2023
PRO Number
Pro00128818
Researcher
Bashar Badran

List of Studies


Keywords
Brain
Summary

Hypermobile EDS and hypermobile spectrum disorder (collectively referred to as hEDS) are estimated to affect 1 in 500 individuals worldwide. hEDS patients have limited treatment options for their numerous symptoms that impact the quality of life. This clinical trial tests a new ear stimulation method in hEDS patients to determine if it may improve quality of life.

Institution
MUSC
Recruitment Contact
Dillon Connolly
843-792-9502
connolld@musc.edu

Evaluating the effects of transcranial focused ultrasound (tFUS) on fronto-striatal resting state functional connectivity in healthy individuals

Date Added
April 4th, 2023
PRO Number
Pro00127562
Researcher
Bashar Badran

List of Studies


Keywords
Healthy Volunteer Studies
Summary

This study is a brain imaging and brain stimulation study that will test a new form of brain stimulation which uses sound. We plan to evaluate whether transcranial focused ultrasound (tFUS), will impact the way the brain communicates 10 healthy individuals. If successful, we will better understand how sound may change brain function.

Institution
MUSC
Recruitment Contact
Dillon Connolly
843-792-9502
connolld@musc.edu

Determining the independent and synergistic effects of transcutaneous auricular neurostimulation (tAN) on direct brain activation in healthy individuals

Date Added
September 6th, 2022
PRO Number
Pro00122682
Researcher
Bashar Badran

List of Studies


Keywords
Healthy Volunteer Studies
Summary

In this research study, healthy participants will receive ear stimulation during brain imaging. Ear stimulation will involve the study team applying small electrodes to the outer part of your left ear and administering small amounts of electrical stimulation that may cause you to feel a "tickling" sensation on your ear. Participants will receive four, 8-min ear stimulation sessions in the scanner, and the order of the sessions is randomly assigned to you.

Knowledge gained from this study will help us better understand how stimulation of nerves in your ear turns on different parts of the brain.

Institution
MUSC
Recruitment Contact
John Robinson
843-792-9502
robinjoh@musc.edu

Evaluating the specific role of endogenous opioids as the mechanism underlying tAN-based analgesia in healthy individuals

Date Added
September 6th, 2022
PRO Number
Pro00122762
Researcher
Bashar Badran

List of Studies


Keywords
Healthy Volunteer Studies
Summary

This study is attempting to understand whether 30-minutes of a new ear stimulation technology can reduce pain in healthy individuals. Participants in this trial will attend two experimental visits, during which they will receive ear stimulation during the intravenous administration (I.V.) of either saline or naloxone. During each visit, the amount of thermal pain participants can tolerate will be determined before and after ear stimulation. Brain scans will also be collected before and after ear stimulation. Each visit should last about 3 hours.

Institution
MUSC
Recruitment Contact
Falon Sutton
843-792-9502
suttonf@musc.edu

Managing Inpatient Neuropsychiatric Conditions Using Wearable Auricular Vagus Stimulation: The iWAVE Pilot Trial

Date Added
June 7th, 2022
PRO Number
Pro00120876
Researcher
Bashar Badran

List of Studies


Keywords
Anxiety, Psychiatry
Summary

This is a research study to find out if mental health symptoms in patients admitted to the Institute of Psychiatry are affected by a form of ear stimulation called transcutaneous auricular vagus nerve stimulation, or taVNS. Participants will receive ear stimulation during their inpatient treatment at the Institute of Psychiatry. Participants will be randomly assigned to either receive ear stimulation for 1 day (up to 9 treatments over the course of a single day) or 3 days (up to 3 treatments per day), and will have a 50:50 chance of being in either group (like the flip of a coin). Each treatment will last up to 30 minutes and there will be a break of at least 30 minutes in between treatments. The study team will ask participants to complete a group of questionnaires at the beginning and end of the study. In addition, there are several questionnaires that will be completed daily while participants are receiving ear stimulation. Participants in the 1 day stimulation group will also receive 2 days of follow up questionnaires after the initial day of stimulation. The questionnaires will ask questions about mental health symptoms that subjects may or may not be experiencing, including questions about mood, anxiety, and sleep. The ear stimulation treatments will not interfere with the care subjects are receiving from the medical team. In order to qualify for this study, participants must be actively receiving inpatient care at the MUSC Institute of Psychiatry.

Institution
MUSC
Recruitment Contact
Dillon Connolly
843-792-9502
connolld@musc.edu



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