Vitamin C, Thiamine and Steroids in Sepsis A multi-center, randomized, placebo-controlled, double-blind, adaptive clinical trial of vitamin C, thiamine and steroids as combination therapy in patients with sepsis. Save

Date Added
October 18th, 2018
PRO Number
Pro00078768
Researcher
Andrew Goodwin

List of Studies


Profiles_link
Keywords
Lung, Pulmonary
Summary

Sepsis is an acute life-threatening illness. Specific aims of this study are to demonstrate the efficacy of combination therapy using vitamin C, thiamine and corticosteroids to reduce the duration of cardiovascular and respiratory organ dysfunction in critically ill patients with sepsis. Additionally, this research study aims to demonstrate the efficacy of combination therapy using vitamin C, thiamine and corticosteroids to reduce 30-day mortality in critically ill patients with sepsis.

Institution
MUSC
Recruitment Contact
Abbi Reed
843-792-1820
reedab@musc.edu

Crystalloids Liberal Or Vasopressors Early Resuscitation In Sepsis Save

Date Added
August 21st, 2018
PRO Number
Pro00078104
Researcher
Andrew Goodwin

List of Studies


Profiles_link
Keywords
Lung, Pulmonary
Summary

This is a research study of different ways to use intravenous fluids (fluids given through a small tube placed in the vein) and vasopressors (medicines used to raise blood pressure) to treat sepsis, which is a serious infection. We are asking you to be in this study because: a) you have been diagnosed with low blood pressure due to an infection and b) your blood pressure has stayed low after your doctors gave you fluids. We do not know which approach is better in this situation: a)starting medicines to raise blood pressure first and then giving more fluids (if needed), or b) giving a larger amount of fluids first and then giving medicines to raise blood pressure if needed. Right now, the choice of approach is left to the doctors. Some doctors use medicines to raise blood pressure followed by extra fluids, and others use extra fluids followed by medicines to raise blood pressure. Some doctors use a combination of the two. This treatment part of the study will last for 24 hours, and then we will follow you until you go back to where you live. We want to find out whether one of these approaches compared to the other can improve a patient's chances of survival.

Institution
MUSC
Recruitment Contact
Abbi Reed
843-792-1820
reedab@musc.edu

The Role of Circulating Micro RNAs in ARDS Pathogenesis and Prognostication Save

Date Added
August 24th, 2016
PRO Number
Pro00057974
Researcher
Andrew Goodwin

List of Studies


Profiles_link
Keywords
Circulation, Pulmonary
Summary

The Acute Respiratory Distress Syndrome (ARDS) is a major cause of mortality and morbidity in critically ill patients. There are no proven effective pharmacologic therapies for the syndrome in part because the current understanding of the causes of ARDS is limited. The aims of this study are to examine the role that extracellular micro RNA play in the endothelial and epithelial dysfunction which occurs in ARDS.

Institution
MUSC
Recruitment Contact
Kelly Krajeck
843-792-8056
krajeck@musc.edu

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