Extending taVNS Paired with Infant CIMT into a Home-Based Setting: Technology Development Requisite for a Randomized Trial

Date Added
January 3rd, 2023
PRO Number
Pro00123579
Researcher
Kelly McGloon

List of Studies

Keywords
Brain, Infant, Movement Disorders, Physical Therapy, Stroke Recovery
Summary

Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body. In older children, therapists may use a hand mitt and restraint for the stronger arm, to encourage use of the weaker side, called constraint-induced movement therapy (CIMT). Even with the high intensity therapy of CIMT, it typically takes between 40-120 hours total treatment time for most children to improve their motor skills. A non-invasive form of nerve stimulation, transcutaneous auricular vagus nerve stimulation (taVNS), stimulates a nerve by the ear that enhances learning motor skills. taVNS stimulation will be triggered by EMG sensors which detect muscle activity. The purpose of this study is to evaluate the safety and effectiveness of taVNS to improve motor skills when paired with CIMT in infants with one-sided weakness at 6-24 months of age.

Institution
MUSC
Recruitment Contact
Kelly McGloon
8437926443
mclgoon@musc.edu

Measurement-Based Stroke Tele- Occupational Therapy to Improve Community and Home Activity Performance

Date Added
December 15th, 2022
PRO Number
Pro00125524
Researcher
Michelle Woodbury

List of Studies


Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

This small stroke rehabilitation study will test the feasibility of a new method to personalize a home exercise program for arm/hand recovery. The research study will last ~8 weeks. Participants will be included if they are adults who have experienced a stroke that has caused one arm/hand to become weak, are able to come to the MUSC main campus 3 times for ~2hr arm movement evaluations, and are willing and able to engage in 60 minute telerehabilitation video visits with an occupational therapist 1-2 times per week for 6 weeks. We anticipate that the results of this study will enable occupational therapists and stroke survivors to, together, design home exercise programs that are meaningful, motivating and effective.

Institution
MUSC
Recruitment Contact
Julianne Laura
843-985-1773
roseju@musc.edu

EMG-Controlled Game to Retrain Upper Extremity Muscle Activation Patterns Following Stroke

Date Added
November 22nd, 2022
PRO Number
Pro00124158
Researcher
Na Jin Seo

List of Studies


Keywords
Rehabilitation Studies, Stroke Recovery
Summary

The purpose of this study is to develop and test if upper limb task practice and muscle activity training improve upper limb function in stroke survivors. Participants will be asked to come to the laboratory 3 times a week for 6 weeks to receive upper limb task practice and/or muscle activity training. Participants will also come to the laboratory for additional 3 visits for assessments of upper extremity function. The total duration of the study will be 2.5 months.

Institution
MUSC
Recruitment Contact
Na Jin Seo
8437920084
NaJin.Seo@va.gov

Examining the association between psychosocial factors and adherence to a home exercise program for upper extremity recovery in Veteran stroke survivors

Date Added
November 18th, 2022
PRO Number
Pro00124150
Researcher
Gabrielle Scronce

List of Studies

Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Research shows that exercising at home can improve arm and hand movement after a stroke. Unfortunately, it can be hard to exercise enough to make a difference in arm and hand movement after stroke. In this study, we will try to determine things that make it easy or hard for Veterans to exercise their arm and hand after a stroke. In this study, we will recruit Veteran stroke survivors who have difficulty using their arm and hand after a stroke. First, we will administer surveys and questionnaires to get Veteran stroke survivors' perspectives on their self-confidence, mood, sleep, and more. Then, we will ask them to track their home exercise using a wearable movement tracker (like a smart watch). Then, Veteran stroke survivors will meet with a researcher to talk about their experience doing home exercise and why they think it was easy or hard to do.

Institution
MUSC
Recruitment Contact
Gabrielle Scronce
334-590-6943
gabrielle.scronce@va.gov

REAL Answers (Registry Expansion Analysis to Learn Answers)

Date Added
November 16th, 2022
PRO Number
Pro00124358
Researcher
Hermes Florez

List of Studies

Keywords
Anxiety, Blood Disorders, Cardiovascular, Genetics, Hypertension/ High Blood Pressure, Pain, Stroke, Stroke Recovery
Summary

Over 2400 people who have sickle cell disease and are between the ages of 15 and 45 have been enrolled into the National Registry (SCDIC-I) of patients with Sickle Cell Disease (SCD). A rich resource of natural history data, the SCDIC-I Registry has longitudinal data collected yearly since 2016 from patient surveys (e.g. self reported pain incidences, sleep, barriers to care, experiences during and after pregnancy), medical record abstraction (e.g. medications, transfusion history, co-morbidities) and laboratory results. The 150 patients (or 1200 among the 8 sites) will be selected from both MUSC adult and pediatric SCD clinics starting at 12 years of age; those not previously enrolled in the SCDIC National Registry will be offered the possibility to enroll in SCDIC-II.
We will look at the following:
1- Compare the effect of new SCD medications – crizanlizumab, voxelotor, and L-glutamine – on clinical outcomes in individuals with SCD.
2 - Identify genetic and genomic predictors of response to crizanlizumab, voxelotor, and L-glutamine
3 - Integrate study data into the CureSCi metadata catalog (MDC) to enhance future cross-study analyses.

Institution
MUSC
Recruitment Contact
Jayla Moss
843-792-4653
mossjay@musc.edu

Characterizing Lower Extremity Neurophysiological Responses to Sensory Augmentation after Stroke

Date Added
November 1st, 2022
PRO Number
Pro00124079
Researcher
Jasmine Cash

List of Studies

Keywords
Stroke, Stroke Recovery
Summary

Following stroke, communication between brain areas and to the lower limbs can be compromised, leading to impairments in walking ability. Paired associative stimulation (PAS), a method of non-invasive brain stimulation, is thought to be a useful tool in understanding the relationship between different parts of the brain, and functional ability. However, PAS protocols have not been optimized for use post-stroke. The purpose of this research study is to determine the reliability and effectiveness PAS. This study involve individuals >6 months after having a stroke.

Institution
MUSC
Recruitment Contact
Jasmine Cash
9804282997
cashja@musc.edu

Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study

Date Added
October 4th, 2022
PRO Number
Pro00120805
Researcher
John Kindred

List of Studies


Keywords
Stroke, Stroke Recovery
Summary

Approximately 50% of people who have had a stroke report feelings of tiredness and/or a lack of energy that is not reduced with rest and sleep. This phenomenon is known as post-stroke fatigue. Post-stroke fatigue negatively affects an individual's quality of life and participation in rehabilitation, social, and physical activities. There are currently no known effective treatment options for people with post-stroke fatigue. This study will investigate the use of a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to treat post-stroke fatigue. This method has proven useful in other conditions such as depression and we will measure the effects of TMS on reducing fatigue in individuals more than six months post-stroke.

Institution
MUSC
Recruitment Contact
Brian Cence
8437922658
cence@musc.edu

Sickle Cell Disease Patient Registry

Date Added
August 23rd, 2022
PRO Number
Pro00122740
Researcher
Hermes Florez

List of Studies

Keywords
Anxiety, Blood Disorders, Cardiovascular, Genetics, Hypertension/ High Blood Pressure, Pain, Stroke, Stroke Recovery
Summary

Over 2400 people who have sickle cell disease and are between the ages of 15 and 45 have been enrolled into the National Registry (SCDIC-I) of patients with Sickle Cell Disease (SCD). A rich resource of natural history data, the SCDIC-I Registry has longitudinal data collected yearly since 2016 from patient surveys (e.g. self reported pain incidences, sleep, barriers to care, experiences during and after pregnancy), medical record abstraction (e.g. medications, transfusion history, comorbidities) and laboratory results. The SCDIC-II Registry will continue follow-up of this patient cohort and enroll new patients of all ages to enrich the data resource as a natural history study.

Institution
MUSC
Recruitment Contact
Sarah Bourne
843-876-8652
bourne@musc.edu

Combining noninvasive brain stimulation and functional neuroimaging in patients with stroke

Date Added
July 19th, 2022
PRO Number
Pro00120319
Researcher
Nathan Rowland

List of Studies


Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Transcranial direct current stimulation (tDCS) can be an effective therapy for stroke recovery patients. However, the extent to which patients show improvements with tDCS is highly variable. This variability may arise due to the differences of stroke location in the brain and because of differences in brain damage, all of which may differ between patients. If the relationship between these factors and tDCS efficacy were known, recovery from stroke using tDCS might become more predictable. Our overall objective is to understand potential measures of tDCS efficacy that may someday allow for optimization of clinical outcomes and patient care.

Institution
MUSC
Recruitment Contact
Brenna Baker-Vogel
843-792-0651
bakebren@musc.edu; salazarc@musc.edu

Developing a Novel Cognitive-Behavioral Intervention for Psychosocial Rehabilitation in Chronic Stroke

Date Added
June 6th, 2022
PRO Number
Pro00118778
Researcher
Lisa McTeague

List of Studies


Keywords
Anxiety, Depression, Stress Disorders, Stroke Recovery
Summary

The purpose of this study is to identify domains in which stroke suvivors may have struggled since experiencing a stroke. These include things like emotional, family and work function. This study entails an interview and questionnaires that ask about functioning in these areas.

The longer-term goal of this work is to identify areas these areas so that we can develop a psychotherapy that could be helpful for individuals recovering from and living with the aftermath of stroke.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
lisa.mcteague@va.gov



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