The purpose of this study is to determine if giving the medicine ?heparin? intravenously (through the veins) continuously for up to 14 days to subjects after a brain aneurysm has burst will help improve the chances of subjects having a good recovery after the bleed compared to subjects who get routine brain aneurysm care (standard of care). Patients who get routine care would also get heparin, but they would typically get an overall lower dose and the heparin would be injected under the skin (heparin shot) instead of in the veins.
This study will recruit adolescents who are enrolled in a Teen Health Careers Program to participate in a community-engaged study. This study will seek to understand the barriers and facilitators to physical activity and nutritious foods throughout their daily lives. Adolescents will use take digital images to capture aspects of their daily lives using photography.
The TRANSFORM network is focused on improving child health outcomes in SC through research on conditions of highest priority for future generations. These include conditions like asthma, autism, diabetes, obesity and early childhood outcomes. To accelerate research study recruitment activities for future projects that TRANSFORM sites may participate in, the TRANSFORM network sites will create a research recruitment registry of families interested in volunteering for research. Participants will enter their own as well as their child(ren)'s information into the electronic registry which can be used to identify people to contact for future studies.
This trial of pitavastatin will determine efficacy and safety in this high risk population, and provide evidence for clinicians to target this treatable risk factor to achieve an impact on early atherosclerosis, and potentially achieve primary prevention of adult cardiovascular disease.
Interviews of adolescents 13-17 years old in rural and urban areas of South Carolina will be conducted to identify which weight management apps adolescents think are easy to use, engaging and motivating, and fit their needs for help with managing weight. Features that adolescents prefer will be gathered and health care providers can use this information to recommend immediately available, engaging, and helpful resources for weight management.
Our long-term goal is to optimize the use of mobile apps as beneficial and readily accessible resources to assist primary care providers in the management of overweight/obese adolescents. However, prior to determining if an app is efficacious or even feasible, adolescents? preferences for app features need to be assessed.
The objective of this research is to determine which features of apps adolescents think appeal or detract from the acceptability and usability of weight management apps. Our central hypothesis is that adolescents will prefer to use some apps more than others and this will most likely be due to the preferred specific features available in certain apps, such as goal setting and social connection with friends, peers, or providers.
We are conducting the INSIGHT COPD study because symptoms of chronic obstructive pulmonary disease (COPD) and high body mass index (BMI) overlap. There are many medications for patients with COPD, but there is little mention of weight loss as a possible treatment in current research. We are trying to find out if a lifestyle program that promotes modest weight loss and increased physical activity will improve COPD symptoms and lead to better exercise tolerance for those with a high BMI. We are also looking at the effects on shortness of breath, quality-of-life, and cardiovascular disease risk factors. The INSIGHT COPD trial is taking place at many sites across the United States including MUSC, and is planning to enroll approximately 1000 people.
The proposed study (ECCHO-NFGS) provides an unprecedented opportunity to understand mechanisms of in utero exposures on risk of childhood outcomes of public health significance. The data are of the highest quality, are the most detailed serial assessments of fetal development available in any cohort. We will demonstrate our ability to engage children and standardize our research protocols to address our hypotheses (UG3) and follow this cohort prospectively for future risk assessment (UH3). The NFGS is the ideal cohort to assess the prenatal determinants of two key health outcomes ? obesity and neuroimpairment as well as be a resource for the ECHO Consortium for all four outcome focus areas.
TARGET-HCC is a 5-year, longitudinal, observational study of the natural history and management of patients with HCC. The study will address important clinical questions that remain unanswered in the management of HCC with a unique research registry of participants with HCC from academic and community real-world practices. TARGET-HCC is disease focused, not drug specific, which allows for continuous acquisition of real-world evidence regarding the natural history, management, and outcomes of treatment with current therapies and new treatments that may be utilized in usual clinical practice.
This is a 5-year, longitudinal, observational study of patients with NAFL or NASH designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a bio specimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.
This study seeks to determine whether liraglutide, the study medication, along with intensive behavior therapy, will help adults who are obese to lose weight over one year. Participants will be randomly assigned to receive liraglutide or an inactive placebo. All participants will receive behavior therapy. Participants will inject themselves daily with study medication. The primary measure of the study will be weight change.