This study enrolls donors and recipients involved in a bone marrow transplant. Donors are participants that are already planning on being a blood and marrow transplant (BMT) donor for a family member. This research study is asking for the donor's permission to take a small number of either the bone marrow cells or the peripheral blood (apheresis) cells for a research project, before they are transplanted into the family member. The extra bone marrow or peripheral blood stem cells will be analyzed in the laboratory. The researchers are trying to determine if there are certain cells, proteins, or genes (DNA) in the donor bone marrow or peripheral blood stem cell product that increase the risk of the recipient getting cGVHD. The recipients are participants that are about to undergo a blood and marrow transplantation (either bone marrow, peripheral blood stem cells, or umbilical cord blood – collectively referred to as “blood and marrow transplantation” or BMT). Chronic graft-versus-host disease (cGVHD) is one of the most important complications following BMT, occurring in around 10-20% of children who receive a transplant. This research study is trying to determine if it is possible to identify children earlier on who are at the highest risk for developing cGVHD. The goal would be to see if we can predict which children are at the highest risk of developing cGVHD after BMT, before cGVHD develops. If it is possible to separate children with lower or higher risks of cGVHD at an earlier time point after BMT (by day 100 post-BMT), it might mean that we could do something to try to prevent cGVHD from forming (e.g. give a medication to the higher risk group). The purpose of this study, however, is only to look at whether we can predict which patients are at a higher or lower risk of cGVHD – it is NOT a medication /drug trial.
South Carolina Coalition for Care of Serious Illness (SCC CSI) sponsors development of Physician Orders for Scope of Treatment (POST) in South Carolina. The SC POST follows the national POLST (www. polst.org) paradigm creating an advance treatment planning physician order that migrates as valid across institutional boundaries: from physician office, to home/nursing home/hospice to EMS to hospital emergency/inpatient services. The POST form encourages a conversation between a physician and the patient regarding treatment options available to seriously ill patients for whom death within a year would not be a surprise. These choices primarily include whether to attempt cardiopulmonary resuscitation in the event of cardiac or pulmonary arrest or not (a “DNR” or “Allow Natural Death” order) and whether during acute illness to provide full treatment including endotracheal intubation and intensive care, supportive treatment such as noninvasive ventilation and no intensive care, or comfort care only. The Charleston and Greenville areas will pilot POST. Investigators by area will survey providers completing POST documents for patients or treating patients with POST about the utility of this form and how use of the form affected their patient's treatment. A chart reviews of patients presenting with a POST form to a hospital emergency or inpatient unit will address whether providers respected patient treatment choices. SCC CSI plans to publish the results of the pilot in appropriate journals and present the results at medical meetings and to interested persons. The results of the study may provide the supporting documentation for subsequent legislation supporting POST. POST represents a coordinated statement of a seriously ill patient’s treatment choices to be honored across multiple treatment settings.
This study is for adult patients with adenocarcinoma of the pancreas. The purpose of this research study is to evaluate the safety and effectiveness of the drugs Gemcitabine and Abraxane in the treatment of adenocarcinoma of the pancreas before surgery. Subjects will have screening tests to determine if he or she is eligible to participate in this study. If subjects are eligible and wish to enroll in the study, they will begin chemotherapy treatment with Gemcitabine and Abrazane. After subjects have received treatment with these drugs, they will have surgery. Subjects will also have post treatment and follow up evaluations. Subjects may have 2 cycles of treatment and each cycle is 28 days. All subjects will be followed every 3 months for 3 years after their initial registration.
This study is for subjects who have inoperable (surgical treatment is not an option) or metastatic (has spread to other parts of the body) urothelial carcinoma (includes cancer of the bladder, urethra, ureter or renal pelvis) and who are not responding to platinum-based chemotherapy (such as carboplatin or cisplatin).
This study will evaluate whether treatment with OGX-427 in combination with docetaxel can prolong survival time compared to treatment with docetaxel alone in patients with urothelial carcinoma (UC) who are no longer responding to treatment with a platinum-based chemotherapy regimen. Docetaxel (also known as Taxotere®) is commercially available and is approved by the Food and Drug Administration (FDA) in the United States for the treatment of breast, stomach, lung, prostate and head and neck cancers. OGX-427 is a new drug that is experimental (not approved by the FDA).
The use of docetaxel in combination with the experimental drug OGX 427 in this study is investigational. “Investigational” means that the combination of drugs is being studied. It also means that the FDA (the U.S. Food and Drug Administration) has not yet approved this combination of drugs.
Subjects in Group A will receive 9 days of loading doses, 10 cycles of combined treatment at 3 weeks per cycle, and maintenance treatment with OGX-427 only until the disease progresses or they experience unacceptable side effects.
Subjects in Group B will receive 10 cycles of docetaxel alone at 3 weeks per cycle, for a total of about 30 weeks. Everyone who completes study treatment with no evidence of disease progression will be followed every 6 weeks until disease progression. Everyone will be followed every 3 months after disease progression for survival.
The purpose of this study is to find out if the switching to the study drug, nilotinib (Tasigna) (AMN107, Tasigna) in people who have Chronic Myeloid Leukemia (CML) can help decrease the number of leukemia cells to a very small number.
This trial is sponsored by the pharmaceutical company named Novartis.
Eligible subjects will receive nilotinib (Tasigna), the study drug, as CML treatment. Nilotinib (Tasigna) is a medicine which has been approved by the United States Food and Drug Administration (FDA) for the treatment of CML. The duration of the study will range from 2 years and up to 6 years.
The purpose of this study is to learn more about reduced-intensity transplants that use a mismatched donor. You are being asked to participate in this study because you have a cancer of the blood or lymph glands and a stem cell transplant is a treatment option.
The purpose of this study is to compare the effects, good and/or bad, of an ACE inhibitor (lisinopril) or a beta-blocker (Coreg CR® [carvedilol phosphate extended release]) on heart function during treatment with trastuzumab (Herceptin®), a drug subjects will receive as treatment for breast cancer. Lisinopril and Coreg CR® are used to treat high blood pressure, heart failure and in heart attack patients. Study doctors want to find out which treatment (lisinopril or Coreg CR®) is better at protecting heart function during treatment of breast cancer. The effect of the medicines will be compared to a placebo, which contains no active drug. Subjects will only get one of the study medicines (lisinopril, Coreg CR® or placebo).
the United States, it is standard treatment for patients with high-risk neuroblastoma (NBL) to receive the drugs carboplatin, etoposide and melphalan (CEM) as the preparative regimen in Consolidation therapy prior to Autologous Stem Cell Transplant (ASCT). BuMel Consolidation therapy has recently been studied in patients with high-risk NBL in some European countries. The findings from those studies indicate that the use of BuMel prior to ASCT may be linked to an increase in the survival rate for patients when compared to CEM. Those studies also indicate that the chance of the disease coming back (a relapse) may be lower among the patients who received BuMel Consolidation therapy. In North America the BuMel combination is considered experimental. In this study, researchers want to find out if a combination of busulfan and melphalan (BuMel) can be given as Consolidation therapy prior to ASCT for subjects with newly diagnosed high-risk NBL. The main goal of this study is to find out what effects, good and/or bad, a BuMel preparative regimen given before ASCT has on people with newly diagnosed high-risk NBL.