The MIND Study: MR Imaging of Neurodegeneration Save

Date Added
August 11th, 2015
PRO Number
Pro00028302
Researcher
Andreana Benitez
Keywords
Aging, Alzheimers, Brain, Dementia, Geriatrics, Healthy Volunteer Studies, Memory Loss
Summary

This is a study of brain aging and Mild Cognitive Impairment (MCI). In this study, we use non-invasive brain MRI techniques and tests of memory and other thinking skills to improve the detection of brain diseases of aging at the very earliest stages. A fasting blood draw will also be performed to help clarify the contribution of blood sugar and cholesterol to brain aging. We are primarily recruiting 80 individuals ages 65-85 who have been diagnosed with Mild Cognitive Impairment (MCI) by their healthcare provider. We are also recruiting individuals ages 65-85 who are cognitively healthy and do not have any significant or unstable medical conditions. This study is sponsored by the NIH and is conducted at MUSC.

If you are interested in this study, please contact us by phone or through: http://bit.ly/MIND-study

Institution
MUSC
Recruitment Contact
Dana Szeles
(843) 876-2475
szeles@musc.edu

Quantifying Normal Swallow Physiology across the Adult Lifespan Save

Date Added
August 4th, 2015
PRO Number
Pro00011566
Researcher
Kendrea Focht
Keywords
Aging, Healthy Volunteer Studies, Minorities
Summary

This study will involve 280 healthy adult participants. We are currently recruiting males 40 years and older and females 60 years and older. Eligible participants include those without history of head and neck cancer, without history of neurological disease (e.g., stroke, Parkinson's disease, etc), without history or chronic obstructive pulmonary disease (COPD), and without history of thyroid, carotid or spine surgery where the surgeon went through the front of your neck. Study is a one-time visit lasting less than 30 minutes, and compensation for time and travel is provided. Study procedures involve filling out 2 brief questionnaires related to swallowing and overall health. Additionally, you will be required to swallow 12 times where a continuous X-ray will be used to evaluate your swallowing function. This study is non-invasive.

Institution
MUSC
Recruitment Contact
Kendrea Garand
843-792-6953
focht@musc.edu

Physician Order for Scope of Treatment (POST): PILOT STUDY Save

Date Added
July 22nd, 2015
PRO Number
Pro00022252
Researcher
Walter Limehouse
Keywords
Aging, Alzheimers, Cancer, Dementia, Ethnicity and Disease, Geriatrics, Heart, HIV / AIDS, Infectious Diseases, Kidney, Liver, Men's Health, Minorities, Nervous System, Pulmonary, Rare Diseases, Women's Health
Summary

South Carolina Coalition for Care of Serious Illness (SCC CSI) sponsors development of Physician Orders for Scope of Treatment (POST) in South Carolina. The SC POST follows the national POLST (www. polst.org) paradigm creating an advance treatment planning physician order that migrates as valid across institutional boundaries: from physician office, to home/nursing home/hospice to EMS to hospital emergency/inpatient services. The POST form encourages a conversation between a physician and the patient regarding treatment options available to seriously ill patients for whom death within a year would not be a surprise. These choices primarily include whether to attempt cardiopulmonary resuscitation in the event of cardiac or pulmonary arrest or not (a ?DNR? or ?Allow Natural Death? order) and whether during acute illness to provide full treatment including endotracheal intubation and intensive care, supportive treatment such as noninvasive ventilation and no intensive care, or comfort care only. The Charleston and Greenville areas will pilot POST. Investigators by area will survey providers completing POST documents for patients or treating patients with POST about the utility of this form and how use of the form affected their patient's treatment. A chart reviews of patients presenting with a POST form to a hospital emergency or inpatient unit will address whether providers respected patient treatment choices. SCC CSI plans to publish the results of the pilot in appropriate journals and present the results at medical meetings and to interested persons. The results of the study may provide the supporting documentation for subsequent legislation supporting POST. POST represents a coordinated statement of a seriously ill patient?s treatment choices to be honored across multiple treatment settings.

Institution
MUSC
Recruitment Contact
Walter Limehouse
792-9705
limehouw@musc.edu

Adaptive Control of Auditory Representations in Listeners with Central Auditory Processing Disorder Save

Date Added
July 9th, 2015
PRO Number
Pro00045668
Researcher
Kenneth Vaden
Keywords
Aging, Brain, Central Nervous System, Healthy Volunteer Studies, Hearing, Language
Summary

As people get older, understanding speech with competing talkers can become more difficult. This may not only involve changes in the ear, but also changes in how well the brain focuses attention on a single talker. This study uses MRI technology to look at the ways in which the brain processes sounds and speech. The MUSC Hearing Research Program is seeking volunteers to participate in a research study investigating the connection between hearing and the brain. We are recruiting healthy adults, ages 45 to 89 years. Payment is provided for participation, and scheduling is flexible. The study involves two to four visits, participants must be able to complete an MRI. If you would like to participate in this research or learn more about our study, please contact us.

Institution
MUSC
Recruitment Contact
Anne Sorrell
(843) 792-5916
sorrella@musc.edu

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) Save

Date Added
March 11th, 2015
PRO Number
Pro00043151
Researcher
Jacobo Mintzer
Keywords
Aging, Alzheimers, Brain
Summary

With this research study, we want to learn if methylphenidate (Ritalin® and others) helps people with Alzheimer?s disease and apathy (lack of interest or concern for things that others find moving or exciting).

Institution
MUSC
Recruitment Contact
Catherine Danner
843-724-2302
catherine.danner@rsfh.com

Multi-site study of the efficacy of speech perception training for hearing-aid users Save

Date Added
January 16th, 2015
IRB Number
20166
Researcher
Judy Dubno
Keywords
Aging, Ears, Hearing, Minorities
Summary

This project, funded by the National Institutes of Health, is recruiting participants for a multi-site study evaluating an auditory training program for people who use hearing aids. This study includes a hearing evaluation, several listening tasks, and 30 hours of participation in a computer-based speech-training program. Native English speakers between the ages of 35 and 89 who have worn hearing aids for at least the past 3 months are currently being recruited. The study requires at least 2 visits per week for a period of 12-15 weeks, scheduled at the participant’s convenience. Compensation for time will be provided and parking validated.

Institution
MUSC
Recruitment Contact
Sara Fultz
843- 792-0667
fultzs@musc.edu

Experimental and Clinical Studies of Presbyacusis Save

Date Added
October 5th, 2009
IRB Number
E-607R
Researcher
Judy Dubno
Keywords
Aging, Brain, Ears, Geriatrics, Healthy Volunteer Studies, Hearing, Minorities
Summary

This project, funded by the National Institutes of Health, is being conducted to determine the effects of aging on hearing, understanding speech, and brain functions. This study will provide a scientific basis for diagnosis, rehabilitation and prevention of hearing loss due to aging. Volunteers who meet the eligibility requirements may enroll in this study, which will include measurements of hearing, making listening judgments of sounds, behavioral tasks, questionnaires, and MRI scanning of the brain. Participants 60 years of age and older with normal hearing or hearing loss are currently being recruited. Three visits of 2-3 hours each are required and scheduling is flexible.

Institution
MUSC
Recruitment Contact
Amanda Maxwell
843-792-5916
maxwelam@musc.edu

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