Cell Modeling of Human Retinal Degenerations: Insights using Patient-Specific Human Induced-Pluripotent Stem Cells (iPSCs) Save

Date Added
March 18th, 2014
PRO Number
Pro00023262
Researcher
Mark Fields
Keywords
Aging, Rehabilitation Studies, Vision/ Eye
Summary

The purpose of this study will be to collect a skin biopsy (skin tissue) or blood sample from each participating patient with retinal degeneration, such as Best’s disease or age-related macular degeneration (AMD), including geographic atrophy (GA). Each skin biopsy or blood sample will be taken to the laboratory of the investigators where skin epithelial cells called fibroblasts, will be induced to make “pluripotent stem cells” or “iPSCs”. These iPSCs will be differentiated into retina epithelial cells which will be tested for their ability to function as new retinal cells in animal models of retinal degeneration. Because these special cells are individualized or patient-specific, they will not be rejected by that individual patient, and thereby represent the first step in a potential future treatment for retinal disease. Cells will also be processed at the New York Stem Cell Foundation IPSC core facility using the procedure described above. The Medical University of South Carolina (MUSC) and New York Stem Cell Foundation (NYSCF) will enter into a material transfer agreement (MTA) initiated by the MUSC Foundation for Research Development. Once MTAs are initiated, samples will be coded at MUSC. Coded samples will be sent via dry ice to ensure full competency to the NYSCF. Samples will remain coded at MUSC and will not be released to the NYSCF. Fibroblasts will be reprogrammed using the method described above and sent back to MUSC (as iPS cells) for the research purposes of this study. Cells will only be identifiable to the NYSCF by disease, sex, and gender. Once cells are received by the NYSCF they receive a number bar code for further processing and are in no way traceable to the patient by the NYSCF. Reprogrammed cells will be stored at the NYSCF biorepository but only shared with the knowledge of MUSC. These samples will be used for the purposes of this study. Any other use will be evaluated by the investigators and the MUSC Foundation for Research Development and the appropriate action taken. Once samples are processed that will not be withdrawn from the biorepository. The NYSCF biorepository is a secure facility with only authorized personnel having access to the facility

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

Using Health Status to Measure Care Coordination Efficacy Save

Date Added
March 12th, 2014
PRO Number
Pro00030602
Researcher
Johnette Simmons
Keywords
ADD/ADHD, Adolescents, Aging, Autism, Brain, Cancer, Cerebral Palsey, Children's Health, Dementia, Depression, Diabetes, Geriatrics, Heart, Hypertension/ High Blood Pressure, Mental Health, Obesity, Pediatrics, Rehabilitation Studies, Spinal Cord, Stroke
Summary

On March 23, 2010, President Barack Obama of the United States of America, signed into law the Patient Protection and Affordable Care Act commonly referred to as health reform. This bill calls immediate attention to better coordinated care between providers of health care and ancillary services. While the health reform law is new, the concept of care coordination in the practical sense is familiar to several health and human service disciplines, such as behavioral healthcare, developmental disability systems of care, medical home models, disease management programs, case management programs, long term care Medicaid waivers, and large healthcare organizations. The aim of this study is to understand what consumers and families expect from care coordination programs and services, and how programs should be designed to ensure the most benefit

Institution
MUSC
Recruitment Contact
Johnette Simmons
843-576-1408
sinjoh@musc.edu

Neural Changes Underlying Speech-Perception Training in the Aging Brain Save

Date Added
November 29th, 2010
IRB Number
19620
Researcher
Mark Eckert
Keywords
Aging, Brain, Ears, Geriatrics, Hearing
Summary

This study is being conducted to learn whether speech understanding improves through prolonged training with speech sounds and how brain function relates to this improvement. This study includes a basic hearing test, tasks pertaining to perception, mood, memory, and reasoning, questionnaires, MRI scanning of the brain, and participation in a computer-based speech-understanding training program customized to the participant’s hearing loss. Volunteers age 60 years and older with hearing loss who have never used hearing aids or used them only briefly are currently being recruited. The study requires approximately 2-3 visits per week for a period of 8-12 weeks, scheduled at the participant’s convenience. Compensation available. For further information please contact Stephanie Cute 843-792-5916 or email: cute@musc.edu

Institution
MUSC
Recruitment Contact
Stephanie Cute
843-792-5916
cute@musc.edu

Experimental and Clinical Studies of Presbyacusis Save

Date Added
October 5th, 2009
IRB Number
E-607R
Researcher
Judy Dubno
Keywords
Aging, Brain, Ears, Geriatrics, Healthy Volunteer Studies, Hearing, Minorities
Summary

This project, funded by the National Institutes of Health, is being conducted to determine the effects of aging on hearing, understanding speech, and brain functions. This study will provide a scientific basis for diagnosis, rehabilitation and prevention of hearing loss due to aging. Volunteers who meet the eligibility requirements may enroll in this study, which will include measurements of hearing, making listening judgments of sounds, behavioral tasks, questionnaires, and MRI scanning of the brain. Participants 40 years of age and older with normal hearing or hearing loss are currently being recruited. Three visits of 2-3 hours each are required and scheduling is flexible.

Institution
MUSC
Recruitment Contact
Loretta Morris
843-792-5916
morrilj@musc.edu